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Review
. 2022 Feb 7;8(2):97.
doi: 10.3390/gels8020097.

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Rakesh K Sindhu  1 , Rubal Gupta  1 , Gaurish Wadhera  1 , Pradeep Kumar  2
Affiliations
Review

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Rakesh K Sindhu et al. Gels. .

Abstract

This study examined the most recent advancements in nanogel production and drug delivery. Phytochemistry is a discipline of chemistry that studies herbal compounds. Herbal substances have aided in the development of innovative remedies for a wide range of illnesses. Several of these compounds are forbidden from being used in medications due to broad medical characteristics and pharmacokinetics. A variety of new technical approaches have been investigated to ameliorate herbal discoveries in the pharmaceutical sector. The article focuses on the historical data for herb-related nanogels that are used to treat a variety of disorders with great patient compliance, delivery rate, and efficacy. Stimulus-responsive nanogels such as temperature responsive and pH-responsive systems are also discussed. Nanogel formulations, which have been hailed as promising targets for drug delivery systems, have the ability to alter the profile of a drug, genotype, protein, peptide, oligosaccharide, or immunogenic substance, as well as its ability to cross biological barriers, biodistribution, and pharmacokinetics, improving efficacy, safety, and patient cooperation.

Keywords: herbal bioactives; hydrogels; nanogels; polysaccharides.

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Conflict of interest statement

The authors declare no conflict of interest, financial or otherwise.

Figures

Figure 1
Figure 1
Different methods of nanogel preparation.
Figure 2
Figure 2
Mechanism of action of covalent crosslinking gel.
Figure 3
Figure 3
pH-responsive nanogels may be activated by an increase in pH caused by environmental change pH responsive nanogels.
Figure 4
Figure 4
Temperature responsive nanogels and drug release from the thermogel.
See this image and copyright information in PMC

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References

    1. Molina M., Asadian-Birjand M., Balach J., Bergueiro J., Miceli E., Calderón M. Stimuli-responsive nanogel composites and their application in nanomedicine. Chem. Soc. Rev. 2015;44:6161–6186. doi: 10.1039/C5CS00199D. - DOI - PubMed
    1. Annabi N., Mithieux S.M., Zorlutuna P., Camci-Unal G., Weiss A.S., Khademhosseini A. Engineered cell-laden human protein-based elastomer. Biomaterials. 2013;34:5496–5505. doi: 10.1016/j.biomaterials.2013.03.076. - DOI - PMC - PubMed
    1. Soni K.S., Desale S.S., Bronich T.K. Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation. J. Control. Release Off. J. Control. Release Soc. 2016;240:109–126. doi: 10.1016/j.jconrel.2015.11.009. - DOI - PMC - PubMed
    1. Riehemann K., Schneider S.W., Luger T.A., Godin B., Ferrari M., Fuchs H. Nanomedicine—Challenge and perspectives. Angew. Chem. Int. Ed. 2009;48:872–897. doi: 10.1002/anie.200802585. - DOI - PMC - PubMed
    1. Singh N., Gill V., Gill P. Nanogel based artificial chaperone technology: An overview. Am. J. Adv. Drug Deliv. 2013;1:271–276.

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