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Review
. 2021 Dec 1;12(1):58.
doi: 10.1007/s12672-021-00454-1.

Mitophagy in carcinogenesis and cancer treatment

Tatiana V Denisenko  1 , Vladimir Gogvadze  1   2 , Boris Zhivotovsky  3   4
Affiliations
Review

Mitophagy in carcinogenesis and cancer treatment

Tatiana V Denisenko et al. Discov Oncol. .

Abstract

In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson's disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.

Keywords: Autophagy; Cancer; Homeostasis; Mitophagy.

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Conflict of interest statement

Authors declare the absence of any competing financial interests. The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic representation of PINK1/Parkin- and receptor-mediated mitophagy (see the text for the details). A PINK1/Parkin-mediated mitophagy, B–D BNIP3- FUNDC1- FKBP8-mediated mitophagy, respectively
Fig. 2
Fig. 2
Mitophagy modulates anticancer therapy (see the text for the details)
See this image and copyright information in PMC

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