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. 2023 Oct;54(5):1250-1257.
doi: 10.1007/s10578-022-01330-x. Epub 2022 Feb 24.

Trends in Prescribing Antipsychotics for Children and Adolescents in Japan: A Descriptive Epidemiological Study Using a Large-Scale Pharmacy Dataset

Sayuri Nakane  1 , Sachiko Tanaka-Mizuno  1   2 , Chika Nishiyama  1   3 , Kenji Kochi  1   4 , Madoka Yamamoto-Sasaki  1 , Masato Takeuchi  1 , Yusuke Ogawa  5 , Yuko Doi  6 , Masaru Arai  7 , Yosuke Fujii  6 , Toshiyuki Matsunaga  7 , Toshiaki A Furukawa  8 , Koji Kawakami  9
Affiliations

Trends in Prescribing Antipsychotics for Children and Adolescents in Japan: A Descriptive Epidemiological Study Using a Large-Scale Pharmacy Dataset

Sayuri Nakane et al. Child Psychiatry Hum Dev. 2023 Oct.

Abstract

Little is known about antipsychotic prescription patterns among children and adolescents in Japan, particularly in outpatient settings. We investigated the prevalence and trends of antipsychotic prescription for outpatients aged ≤ 17 years receiving a first antipsychotic prescription from 2006 to 2012 based on a large-scale dispensation dataset. Measurements included age, sex, department of diagnosis and treatment, type of prescription (monotherapy or polytherapy), antipsychotic dosage, and concomitant psychotropic drugs. Of the 10,511 patients, 65.1% were aged 13-17 years, and 52.9% were males. Second-generation antipsychotic monotherapy prescriptions increased from 53.8% in 2006 to 78.3% in 2012. Risperidone was the most frequently prescribed antipsychotic, followed by aripiprazole and olanzapine. Approximately 25.0% of patients were prescribed an initial dose less than recommended. Second-generation antipsychotic monotherapy is currently the most frequent prescription pattern among outpatients aged ≤ 17 years receiving an initial antipsychotic prescription.

Keywords: A large-scale dataset; Adolescents; Antipsychotics; Children; Outpatients; Prescribing trends.

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