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Book

Cytomegalovirus Corneal Endotheliitis

Kun Ding  1 , Nathaniel Nataneli  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Cytomegalovirus Corneal Endotheliitis

Kun Ding et al.
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Excerpt

Corneal endotheliitis is defined as corneal endothelium-specific inflammation, which Khodadoust and Attarzadeh first described in 1982, characterized by corneal edema, keratic precipitates (KP), mild anterior chamber (AC) inflammation, and endothelial dysfunction. Based on the presentation of KP and pattern of the overlying stromal and epithelial edema, corneal endotheliitis can be classified into four types: linear, sectoral, disciform, and diffuse.

Viruses including herpes simplex virus (HSV), varicella-zoster virus (VZV), or human herpesvirus 7 (HHV-7) have been reported in association with corneal endotheliitis. In 2006, Koizumi reported the first case of corneal endotheliitis caused by CMV. CMV endotheliitis can present with linear or coin-shaped KP with or without cornea edema in immunocompetent individuals. It may be accompanied by anterior uveitis and increased intraocular pressure (IOP).

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Conflict of interest statement

Disclosure: Kun Ding declares no relevant financial relationships with ineligible companies.

Disclosure: Nathaniel Nataneli declares no relevant financial relationships with ineligible companies.

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References

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