Losing sleep with age

Laura H Jacobson^{1

2

3}, Daniel Hoyer^{1

2

4}

Affiliations

¹ Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
² Department of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.
³ Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Parkville, VIC, Australia.
⁴ Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Comment

Laura H Jacobson et al. Science. 2022.

. 2022 Feb 25;375(6583):816-817.

doi: 10.1126/science.abo1822. Epub 2022 Feb 24.

Laura H Jacobson^{1

2

3}, Daniel Hoyer^{1

2

4}

¹ Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
² Department of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.
³ Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Parkville, VIC, Australia.
⁴ Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Abstract

Hypocretin neuron hyperexcitability underlies disrupted sleep quality associated with age.

Hyperexcitable arousal circuits drive sleep instability during aging.
Li SB, Damonte VM, Chen C, Wang GX, Kebschull JM, Yamaguchi H, Bian WJ, Purmann C, Pattni R, Urban AE, Mourrain P, Kauer JA, Scherrer G, de Lecea L. Li SB, et al. Science. 2022 Feb 25;375(6583):eabh3021. doi: 10.1126/science.abh3021. Epub 2022 Feb 25. Science. 2022. PMID: 35201886 Free PMC article.