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Review
. 2022 May 1;95(1133):20211241.
doi: 10.1259/bjr.20211241. Epub 2022 Feb 24.

Wireless localisation of breast lesions with MagSeed. A radiological perspective of 300 cases

Fotios Constantinidis  1 , Sophia Sakellariou  2 , Sau Lee Chang  2 , Svetlana Linder  2 , Barbara MacPherson  3 , Subodh Seth  4 , Nicola Gill  1 , Archana Seth  2
Affiliations
Review

Wireless localisation of breast lesions with MagSeed. A radiological perspective of 300 cases

Fotios Constantinidis et al. Br J Radiol. .

Abstract

Objectives: The purpose of this article is to review the technical and radiological aspects of MagSeed® localisation, to assess its accuracy based on post-localisation mammograms and excision specimen X-rays and to discuss the radiological experience of our institutions.

Methods: Two-year data were collected retrospectively from three NHS boards from the West of Scotland. A total of 309 MagSeeds® were inserted under mammographic or ultrasonographic guidance in 300 women with unifocal, multifocal and/or bilateral breast lesions at the day of surgery or up to 30 days prior to it. Radiological review of post-localisation mammograms and intraoperative specimen X-rays as well as a review of the surgical outcomes were performed to assess the accuracy and efficacy of the method. Our experience relating to the technique's strengths and downsides were also noted.

Results: The MagSeeds® were inserted on average 7.2 days before surgery. The localisation technique was straight forward for the radiologists. In 99% of the cases, the MagSeed® was successfully deployed and 100% of the successfully localised lesions were excised at surgery. There was no difference in the accuracy of the localisation whether this was mammographically or ultrasonographically guided. On post-localisation mammograms, the MagSeed® was radiologically accurately positioned in 97.3% of the cases. No delayed MagSeed® migration was observed. On the specimen X-rays, the lesion was centrally positioned in 45.1%, eccentric within more than 1 mm from the margin in 35.7% and in 14.8% it was at the specimen's margin. The re-excision rate was 18.3%.

Conclusion: The MagSeed® is an accurate and reliable localisation method in breast conserving surgery with good surgical outcomes.

Advances in knowledge: To our knowledge, the radiological aspects of MagSeed® localisation have not been widely described in peer-reviewed journals thus far.

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Figures

Figure 1.
Figure 1.
MagSeed® with 18-gauge steel needle and wax plug.
Figure 2.
Figure 2.
(From top left to bottom right) a. ultrasonographic appearances of an impalpable invasive ductal carcinoma, b. lesion with introducer in situ, c. MagSeed® visible as an intensely hyperechoic, linear, metallic artefact with minimal posterior acoustic shadowing within the lesion following localisation, d. craniocaudal and e. mediolateral views post-localisation mammograms with MagSeed® visible within the lesion, f. specimen X-ray depicting MagSeed® and lesion slightly eccentrically within the excision specimen.
Figure 3.
Figure 3.
a. Axial and b. Sagittal views of an inserted MagSeed® with associated artefact on dynamic, contrast enhanced breast MRI
See this image and copyright information in PMC

References

    1. Kopans DB, DeLuca S . A modified needle-hookwire technique to simplify preoperative localization of occult breast lesions . Radiology 1980. ; 134( 3 ): 781 . doi: 10.1148/radiology.134.3.7355235 - DOI - PubMed
    1. Chan BKY, Wiseberg-Firtell JA, Jois RHS, Jensen K, Audisio RA . Localization techniques for guided surgical excision of non-palpable breast lesions . Cochrane Database Syst Rev 2015. ; 12: CD009206 . doi: 10.1002/14651858.CD009206.pub2 - DOI - PMC - PubMed
    1. Luini A, Zurrida S, Galimberti V, Paganelli G . Radioguided surgery of occult breast lesions . Eur J Cancer 1998. ; 34: 204 – 5 . doi: 10.1016/s0959-8049(97)00376-6 - DOI - PubMed
    1. Goudreau SH, Joseph JP, Seiler SJ . Preoperative radioactive seed localization for nonpalpable breast lesions: technique, pitfalls, and solutions . Radiographics 2015. ; 35: 1319 – 34 . doi: 10.1148/rg.2015140293 - DOI - PubMed
    1. Pieri A, Milligan R, Critchley A, O’Donoghue JM, Sibal N, et al. . The introduction of radioactive seed localisation improves the oncological outcome of image guided breast conservation surgery . Breast 2017. ; 36: 49 – 53 : S0960-9776(17)30576-3 . doi: 10.1016/j.breast.2017.09.004 - DOI - PubMed