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. 2022 Feb 16;10(1):32.
doi: 10.3390/pharmacy10010032.

The Effect of the NorGeP-NH on Quality of Life and Drug Prescriptions in Norwegian Nursing Homes: A Randomized Controlled Trial

Enrico Callegari  1   2 , Jurate Šaltytė Benth  3   4   5 , Geir Selbæk  2   6   7 , Cato Grønnerød  1   8 , Sverre Bergh  5   6
Affiliations

The Effect of the NorGeP-NH on Quality of Life and Drug Prescriptions in Norwegian Nursing Homes: A Randomized Controlled Trial

Enrico Callegari et al. Pharmacy (Basel). .

Abstract

Background: The effect of the Norwegian General Practice-Nursing Home (NorGeP-NH) criteria has never been tested on clinical outcomes in nursing home (NH) residents. We performed a cluster-randomized trial in Norwegian NHs and tested the effect of NorGeP-NH on QoL (primary outcome), medication prescriptions, and physical and mental health (secondary outcomes) for the enrolled residents; Methods: Fourteen NHs were randomized into intervention NHs (iNHs) and control NHs (cNHs). After baseline data collection, physicians performed NorGeP-NH on the enrolled residents. We assessed the difference between cNHs and iNHs in the change in primary outcome from baseline to 12 weeks and secondary outcomes from baseline to eight and 12 weeks by linear mixed models; Results: One hundred and eight residents (13 lost to follow-up) and 109 residents (nine lost to follow-up) were randomized to iNHs and cNHs, respectively. Difference in change in QoL at 12 weeks between cNHs and iNHs was not statistically significant (mean (95% CI)): -1.51 (-3.30; 0.28), p = 0.101). We found no significant change in drug prescriptions over time. Difference in depression scores between cNHs and iNHs was statistically significant after 12 weeks.

Conclusions: Our intervention did not affect QoL or drug prescriptions, but reduced depression scores in the iNHs. NorGeP-NH may be a useful tool, but its effect on clinical outcomes may be scarce in NH residents. Further studies about the effectiveness of NorGeP-NH in other healthcare contexts and settings are recommended.

Keywords: nursing homes; psychotropic polypharmacy; structured drug review.

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Conflict of interest statement

G.S. has received honoraria for participating in a meeting of the Norwegian advisory board for Biogen regarding the aducanumab trials. The other named authors have no conflicts of interest, financial or otherwise.

Figures

Figure 1
Figure 1
Flowchart of the trial. NH, nursing home.
See this image and copyright information in PMC

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