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. 2022 Feb 11;7(2):25.
doi: 10.3390/tropicalmed7020025.

Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies

Rattagan Kajeekul  1 , Somchai Insiripong  1 , Athita Riwlord  2 , Suleeporn Poomchuchit  3 , Anusak Kerdsin  3
Affiliations

Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia with Cholestatic Hepatitis in a Patient with Anti-Interferon-γ (IFN-γ) Autoantibodies

Rattagan Kajeekul et al. Trop Med Infect Dis. .

Abstract

Francisella is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of Francisella sp. (strain IDAMR664) from the blood of a patient with anti-interferon-γ (IFN-γ) autoantibodies who presented with septicemia and cholestatic hepatitis. Analysis of the strain IDAMR664 genome sequence revealed the isolate was closely related to the strain GA01-2794 that had been isolated from a human in the USA. In addition, it was clustered with F. orientalis, a fish pathogen. The isolate contained several virulence factors and had Francisella pathogenicity island pattern no. 3.

Keywords: Francisella philomiragia; anti-interferon-γ autoantibodies; genome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Whole-genome phylogeny analysis of Francisella clade-2 species generated using CSI phylogeny and visualized with an interactive life tool tree. Francisella strain IDAMR664 in this study is highlighted in yellow. Presentation of the antimicrobial-resistance gene, FPH-1, is shown by filled squares.
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