Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 18;9(2):33.
doi: 10.3390/vetsci9020033.

Hyperbaric Oxygen Therapy in Systemic Inflammatory Response Syndrome

Débora Gouveia  1   2 , Mariana Chichorro  3 , Ana Cardoso  1 , Carla Carvalho  1 , Cátia Silva  1 , Tiago Coelho  1 , Isabel Dias  3 , António Ferreira  4   5 , Ângela Martins  1   2   5   6
Affiliations

Hyperbaric Oxygen Therapy in Systemic Inflammatory Response Syndrome

Débora Gouveia et al. Vet Sci. .

Abstract

(1) Background: Systemic inflammatory response syndrome (SIRS) can occur due to a large number of traumatic or non-traumatic diseases. Hyperbaric oxygen therapy (HBOT) may be used as a main or adjuvant treatment for inflammation, leading to the main aim of this study, which was to verify the applicability of HBOT as a safe and tolerable tool in SIRS-positive dogs. (2) Methods: This prospective cohort study included 49 dogs who showed two or more parameters of SIRS, divided into the Traumatic Study Group (n = 32) and the Non-Traumatic Study Group (n = 17). All dogs were submitted to HBOT for 60-90 min sessions, with 2.4-2.8 ATA. (3) Results: This study revealed that 73.5% (36/49) of dogs showed improvement, and the minimum number of HBOT sessions was two, with a mean of 12.73. The number of days between diagnosis and the beginning of HBOT showed statistical significance (p = 0.031) relative to the clinical outcome. No dogs showed any major side effects. (4) Conclusions: We concluded that HBOT may be safe and tolerable for SIRS-positive dogs, and that it should be applied as early as possible.

Keywords: ATA; HBOT; SIRS; dogs; traumatic.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Diagram used for the admission of dogs in the clinical study. TSG, Traumatic Study Group; NTSG, Non-Traumatic Study Group; HBOT, Hyperbaric Oxygen Therapy.
Figure 2
Figure 2
Dog placement inside the hyperbaric oxygen chamber.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest. 1992;101:1644–1655. doi: 10.1378/chest.101.6.1644. - DOI - PubMed
    1. De Laforcade A. Systemic Inflammatory Response Syndrome. In: Silverstein D.C., Hopper K., editors. Small Animal Critical Care Medicine. 2nd ed. Elsevier Saunders; St. Louis, MO, USA: 2015. pp. 30–34.
    1. Kirby R. An introduction to SIRS and the Rule of 20. In: Kirby R., Linklater A., editors. Monitoring and Intervention for the Critically Ill Small Animal: The Rule of 20. John Wiley & Sons; Hoboken, NJ, USA: 2017. pp. 1–8.
    1. Wu M.-Y., Yiang G.-T., Liao W.-T., Tsai A.P.-Y., Cheng Y.-L., Cheng P.-W. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell. Physiol. Biochem. 2018;46:1650–1667. doi: 10.1159/000489241. - DOI - PubMed
    1. Oley M.H., Oley M.C., Islam A.A., Hatta M., Faruk M., Noersasongko A.D. Hyperbaric oxygen therapy in managing systemic inflammatory response syndrome caused by ischemia-reperfusion injury following hand replantation and long-term outcomes: A report of two cases. Ann. Med. Surg. 2020;60:155–161. doi: 10.1016/j.amsu.2020.10.023. - DOI - PMC - PubMed