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Review
. 2022 Feb 10;11(4):618.
doi: 10.3390/cells11040618.

Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors

Andrigo Barboza de Nardi  1 , Rodrigo Dos Santos Horta  2 , Carlos Eduardo Fonseca-Alves  3   4 , Felipe Noleto de Paiva  1 , Laís Calazans Menescal Linhares  1 , Bruna Fernanda Firmo  5 , Felipe Augusto Ruiz Sueiro  6 , Krishna Duro de Oliveira  7 , Silvia Vanessa Lourenço  8 , Ricardo De Francisco Strefezzi  9 , Carlos Henrique Maciel Brunner  10 , Marcelo Monte Mor Rangel  11 , Paulo Cesar Jark  12 , Jorge Luiz Costa Castro  13 , Rodrigo Ubukata  14 , Karen Batschinski  14 , Renata Afonso Sobral  15 , Natália Oyafuso da Cruz  16 , Adriana Tomoko Nishiya  17 , Simone Crestoni Fernandes  18 , Simone Carvalho Dos Santos Cunha  19 , Daniel Guimarães Gerardi  20 , Guilherme Sellera Godoy Challoub  21 , Luiz Roberto Biondi  22 , Renee Laufer-Amorim  23 , Paulo Ricardo de Oliveira Paes  2 , Gleidice Eunice Lavalle  24 , Rafael Ricardo Huppes  25 , Fabrizio Grandi  26 , Carmen Helena de Carvalho Vasconcellos  27 , Denner Santos Dos Anjos  1   28 , Ângela Cristina Malheiros Luzo  29 , Julia Maria Matera  30 , Miluse Vozdova  31 , Maria Lucia Zaidan Dagli  32
Affiliations
Review

Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors

Andrigo Barboza de Nardi et al. Cells. .

Abstract

Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field. It represents the third most common tumor subtype, and is the most common malignant skin tumor in dogs, corresponding to 11% of skin cancer cases. The objective of this critical review was to present the report of the 2nd Consensus meeting on the Diagnosis, Prognosis, and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors, which was organized by the Brazilian Association of Veterinary Oncology (ABROVET) in August 2021. The most recent information on cutaneous and subcutaneous mast cell tumors in dogs is presented and discussed.

Keywords: cutaneous; dog; mast cell tumor; subcutaneous.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Canine mast cell tumors evidencing different clinical presentations. (A) Solitary, well-delimited and alopecic lesion in a dog. (B) Solitary irregular erythematous and partially alopecic cutaneous lesion. (C) Disseminated lesion with cutaneous/subcutaneous involvement and limb edema. (D) Multiple lesions with ulceration aspect.
Figure 2
Figure 2
Cytological analysis of a cutaneous well-differentiated mast cell tumor stained with Giemsa. It is observed a round ell population, showing a high degree of cytoplasmic granulation. Granules are also observed in the slide background. Objective: 40×.
Figure 3
Figure 3
Photomicrograph of a canine mast cell tumor, revealing a round cell proliferation, with evident nucleolus and moderate cytoplasmic granulation. Hematoxylin and eosin staining, Objective: 40×.
Figure 4
Figure 4
Ki67 and KIT immunoexpression in canine mast cell tumors. (A) Ki67 expression in a mast cell tumor showing more than 23 positive cells (arrows–brown staining). (B) KIT immunohistochemistry revealing pattern II (focal cytoplasmic–arrows). Harris hematoxylin counterstaining.
See this image and copyright information in PMC

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