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Review
. 2022 Feb 1;11(2):191.
doi: 10.3390/antibiotics11020191.

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

Jessica Ceramella  1 , Domenico Iacopetta  1 , Alessia Catalano  2 , Francesca Cirillo  1 , Rosamaria Lappano  1 , Maria Stefania Sinicropi  1
Affiliations
Review

A Review on the Antimicrobial Activity of Schiff Bases: Data Collection and Recent Studies

Jessica Ceramella et al. Antibiotics (Basel). .

Abstract

Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic and organic chemistry. They are used as dyes, catalysts, polymer stabilizers, luminescence chemosensors, catalyzers in the fixation of CO2 biolubricant additives and have been suggested for solar energy applications as well. Further, a wide range of pharmacological and biological applications, such as antimalarial, antiproliferative, analgesic, anti-inflammatory, antiviral, antipyretic, antibacterial and antifungal uses, emphasize the need for SB synthesis. Several SBs conjugated with chitosan have been studied in order to enhance the antibacterial activity of chitosan. Moreover, the use of the nanoparticles of SBs may improve their antimicrobial effects. Herein, we provide an analytical overview of the antibacterial and antifungal properties of SBs and chitosan-based SBs as well as SBs-functionalized nanoparticles. The most relevant and recent literature was reviewed for this purpose.

Keywords: Schiff bases; antibacterials; antimicrobials; chitosan; chitosan-based Schiff bases; imine; nanoparticles.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Main properties and uses of Schiff bases.
Figure 2
Figure 2
Keto–enol equilibrium of 34 and 35 SBs.
See this image and copyright information in PMC

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