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Review
. 2022 Jan 20;12(2):250.
doi: 10.3390/diagnostics12020250.

Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

Ivana Kholová  1   2 , Elina Haaga  1   2 , Jaroslav Ludvik  3 , David Kalfert  4 , Marie Ludvikova  5
Affiliations
Review

Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

Ivana Kholová et al. Diagnostics (Basel). .

Abstract

Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diagnosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.

Keywords: Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP); The Bethesda System for Reporting Thyroid Cytopathology; cytology; histopathology; molecular diagnosis; thyroid gland; thyroid papillary carcinoma; ultrasound.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Classification of follicular—patterned thyroid tumours with papillary-like nuclear feature. (Abbreviations: FVPTC, follicular variant of papillary thyroid carcinoma; iEFVPTC, invasive encapsulated follicular variant of papillary thyroid carcinoma; NIFTP, noninvasive follicular thyroid neoplasm with papillary–like nuclear features).
Figure 2
Figure 2
Encapsulated thyroid tumour formed by microfollicles fulfilling the histopathological criteria of NIFTP. Original magnification 100×.
See this image and copyright information in PMC

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