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Review
. 2022 Feb 15;9(2):261.
doi: 10.3390/children9020261.

You Cannot Hit Snooze on OSA: Sequelae of Pediatric Obstructive Sleep Apnea

Selena Thomas  1 , Shefali Patel  2 , Prabhavathi Gummalla  3 , Mary Anne Tablizo  2   4 , Catherine Kier  1
Affiliations
Review

You Cannot Hit Snooze on OSA: Sequelae of Pediatric Obstructive Sleep Apnea

Selena Thomas et al. Children (Basel). .

Abstract

Pediatric obstructive sleep apnea (OSA) has been shown to not only affect the quality of sleep, but also overall health in general. Untreated or inadequately treated OSA can lead to long-term sequelae involving cardiovascular, endothelial, metabolic, endocrine, neurocognitive, and psychological consequences. The physiological effects of pediatric OSA eventually become pathological. As the complex effects of pediatric OSA are discovered, they must be identified early so that healthcare providers can be better equipped to treat and even prevent them. Ultimately, adequate management of OSA improves overall quality of life.

Keywords: cardiovascular disease; continuous positive airway pressure; endothelial dysfunction; intermediate mechanisms; metabolic dysfunction; neurocognitive impairment; obstructive sleep apnea sequelae; pediatric obstructive sleep apnea; psychosomatic syndromes; sleep-disordered breathing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Sequelae of pediatric obstructive sleep apnea. (a) HTN = hypertension; CHF = congestive heart failure; CAD = coronary artery disease. (b) PVD = peripheral vascular disease. (c) HLD = hyperlipidemia. (d) ADHD = attention-deficit/hyperactivity disorder. (e) GAD = generalized anxiety disorder; MDD = major depressive disorder.
Figure 2
Figure 2
Metabolic alterations of obstructive sleep apnea. LDL = low-density lipoprotein; TG = triglyceride; BP = blood pressure; HDL = high-density lipoprotein.
See this image and copyright information in PMC

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