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. 2022 Feb 21;19(4):2485.
doi: 10.3390/ijerph19042485.

Epidemiology of Fungal Colonization in Children Treated at the Department of Oncology and Hematology: Single-Center Experience

Joanna Klepacka  1 , Zuzanna Zakrzewska  2 , Małgorzata Czogała  2   3 , Magdalena Wojtaszek-Główka  4 , Emil Krzysztofik  4 , Wojciech Czogała  1   2 , Szymon Skoczeń  1   2
Affiliations

Epidemiology of Fungal Colonization in Children Treated at the Department of Oncology and Hematology: Single-Center Experience

Joanna Klepacka et al. Int J Environ Res Public Health. .

Abstract

Oncological patients are especially predisposed to fungal infections due to multiple risk factors and immunocompromising treatment. Epidemiological research regarding pediatric oncologic patients is still insufficient, and existing data are difficult to generalize on different populations. Therefore, we aimed to analyze fungal infections and fungal epidemiology in the Department of Oncology and Hematology of the University Children's Hospital in Krakow with help from the Clinical Microbiology Department. During the chosen period of 2005 and 2015-2020, 2342 tests were performed in our ward on 847 patients. Analyzed samples were divided into five source groups. The amount of patients with positive test results was 62.5%. The year with the highest detection level was 2005. The most frequent pathogen was Candida albicans, with a significant decrease in tendency. An increase in non-albicans species was observed. Candida parapsilosis was not frequently observed compared to similar studies. We noticed an increase in positive results from the urinary tract material. Our results confirmed that fungal infections are still an issue, and they may indicate the efficacy of prophylaxis. The majority of our results are consistent with the literature, yet we managed to emphasize data unique to our patients' population. Our findings are helpful in clinical work and for further studies in our center.

Keywords: Candida albicans; Candida spp.; candidiasis; fungal infection; hematology; mycology; pediatric oncology; yeast.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mycological tests performed in DOH in the studied years, including positive results.
Figure 2
Figure 2
Prevalence of patients with positive mycological tests in the studied years.
Figure 3
Figure 3
Most frequently isolated yeast species and Saccharomyces from clinical samples each year.
Figure 4
Figure 4
Number of mycological samples divided into 5 source groups.
Figure 5
Figure 5
Yeast species and Saccharomyces isolated from the gastrointestinal tract in the studied years.
See this image and copyright information in PMC

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