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Review
. 2022 Feb 13;11(4):979.
doi: 10.3390/jcm11040979.

Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence

Paula Dudek  1 , Paweł Andruszkiewicz  1 , Remigiusz Gelo  1 , Rafael Badenes  2 , Federico Bilotta  3
Affiliations
Review

Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence

Paula Dudek et al. J Clin Med. .

Abstract

This systematic review presents clinical evidence on early and long-term cerebral diseases in liver transplant recipients. The literature search led to the retrieval of 12 relevant studies. Early postoperative cerebral complications include intracranial hemorrhage associated with a coexisting coagulopathy, perioperative hypertension, and higher MELD scores and is more frequent in critically ill recipients; central pontine and extrapontine myelinolysis are associated with notable perioperative changes in the plasma Na+ concentration and massive transfusion. Long-term follow-up cerebral complications include focal brain lesions, cerebrovascular diseases, and posterior reversible encephalopathy; there is no proven relationship between the toxicity immunosuppressive drugs and cerebral complications. This SR confirms a very low incidence of opportunistic cerebral infections.

Keywords: early postoperative complications; intracranial hemorrhage; liver transplantation; long-term follow-up complications; postoperative cerebral infection after liver transplant; postoperative neurological complications.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
ICH, intracranial hemorrhage; CPM/EPM, central pontine and extrapontine myelinolysis; PRES, posterior reversible encephalopathy.
See this image and copyright information in PMC

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