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. 2022 Jan 18;12(2):126.
doi: 10.3390/jpm12020126.

Betel Nut Chewing Is Associated with the Risk of Kidney Stone Disease

Chun-Kai Chang  1   2 , Jia-In Lee  3 , Chu-Fen Chang  4 , Yung-Chin Lee  1   2 , Jhen-Hao Jhan  1   2 , Hsun-Shuan Wang  1   2 , Jung-Tsung Shen  1 , Yao-Hsuan Tsao  1   2 , Shu-Pin Huang  2   5   6   7 , Jiun-Hung Geng  1   2   5   6   7   8
Affiliations

Betel Nut Chewing Is Associated with the Risk of Kidney Stone Disease

Chun-Kai Chang et al. J Pers Med. .

Abstract

(1) Background: Betel nut chewing injures bodily health. Although, the relationship between betel nut chewing and kidney stone disease (KSD) is unknown. (2) Methods: We analyzed 43,636 men from Taiwan Biobank. We divided them into two groups on the status of betel nut chewing, the never-chewer and ever-chewer groups. Self-reported diagnosed KSD was defined as the subject's medical history of KSD in the questionnaire. Logistic regression was used to analyze the association of betel nut chewing and the risk of KSD. (3) Results: The mean age of subjects in the present study was 50 years, and 16% were ever-chewers. KSD was observed in 3759 (10.3%) and 894 (12.6%) participants in the group of never-chewer and ever-chewer groups, respectively. Higher risk of KSD was found in participants with betel nut chewing compared with to without betel nut chewing (odds ratio (OR), 1.094; 95% confidence interval (95% CI), 1.001 to 1.196). Furthermore, the daily amounts of betel nut chewing >30 quids was associated with a more than 1.5-fold increase (OR, 1.571; 95% CI, 1.186 to 2.079) in the odds of KSD; (4) Conclusions: Our study suggests that betel nut chewing is associated with the risk of KSD and warrants further attention to this problem.

Keywords: areca nut; betel nut; epidemiologic study; kidney stone disease; nephrolithiasis; risk factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study participants were classified by status of betel nut.
See this image and copyright information in PMC

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References

    1. Lotan Y. Economics and Cost of Care of Stone Disease. Adv. Chronic Kidney Dis. 2009;16:5–10. doi: 10.1053/j.ackd.2008.10.002. - DOI - PubMed
    1. Rule A.D., Krambeck A.E., Lieske J.C. Chronic Kidney Disease in Kidney Stone Formers. Clin. J. Am. Soc. Nephrol. 2011;6:2069–2075. doi: 10.2215/CJN.10651110. - DOI - PMC - PubMed
    1. Ando R., Nagaya T., Suzuki S., Takahashi H., Kawai M., Okada A., Yasui T., Kubota Y., Umemoto Y., Tozawa K., et al. Kidney Stone Formation is Positively Associated with Conventional Risk Factors for Coronary Heart Disease in Japanese Men. J. Urol. 2013;189:1340–1346. doi: 10.1016/j.juro.2012.11.045. - DOI - PubMed
    1. Hamano S., Nakatsu H., Suzuki N., Tomioka S., Tanaka M., Murakami S. Kidney stone disease and risk factors for coronary heart disease. Int. J. Urol. 2005;12:859–863. doi: 10.1111/j.1442-2042.2005.01160.x. - DOI - PubMed
    1. Lu Y.-M., Chien T.-M., Li C.-C., Chou Y.-H., Wu W.-J., Huang C.-N. Urolithiasis is associated with the increased risk for osteoporosis: A nationwide 9-year follow-up study. Urol. Sci. 2018;29:145–150.

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