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Review
. 2022 Feb 2;12(2):205.
doi: 10.3390/jpm12020205.

Personalized Dosimetry in Targeted Radiation Therapy: A Look to Methods, Tools and Critical Aspects

Rachele Danieli  1 , Alessia Milano  2   3 , Salvatore Gallo  4   5 , Ivan Veronese  4   5 , Alessandro Lascialfari  6 , Luca Indovina  2 , Francesca Botta  7 , Mahila Ferrari  7 , Alessandro Cicchetti  8 , Davide Raspanti  9 , Marta Cremonesi  10
Affiliations
Review

Personalized Dosimetry in Targeted Radiation Therapy: A Look to Methods, Tools and Critical Aspects

Rachele Danieli et al. J Pers Med. .

Abstract

Targeted radiation therapy (TRT) is a strategy increasingly adopted for the treatment of different types of cancer. The urge for optimization, as stated by the European Council Directive (2013/59/EURATOM), requires the implementation of a personalized dosimetric approach, similar to what already happens in external beam radiation therapy (EBRT). The purpose of this paper is to provide a thorough introduction to the field of personalized dosimetry in TRT, explaining its rationale in the context of optimization and describing the currently available methodologies. After listing the main therapies currently employed, the clinical workflow for the absorbed dose calculation is described, based on works of the most experienced authors in the literature and recent guidelines. Moreover, the widespread software packages for internal dosimetry are presented and critical aspects discussed. Overall, a selection of the most important and recent articles about this topic is provided.

Keywords: molecular radiation therapy; personalized dosimetry; selective intra-arterial radiation therapy; targeted radiation therapy; treatment planning systems.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
MRT clinical dosimetric workflow.
Figure 2
Figure 2
Time–activity curve (TAC) with interpolation and extrapolation areas.
Figure 3
Figure 3
Dosimetric approaches in a figurative accuracy–speed plane.
Figure 4
Figure 4
Concept map of the two possible approaches to calculate an absorbed dose map.
See this image and copyright information in PMC

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