Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 7;12(2):229.
doi: 10.3390/jpm12020229.

Scabies Infestation and Risk of Acute Myocardial Infarction: A Population-Based Cohort Study

Yao-Ping Ko  1 , Pei-Yun Chen  2   3 , Chung Y Hsu  4 , Renin Chang  1 , Kai-Chieh Hu  5   6 , Lu-Ting Chiu  5 , Yao-Min Hung  7   8   9 , Guang-Yuan Mar  7
Affiliations

Scabies Infestation and Risk of Acute Myocardial Infarction: A Population-Based Cohort Study

Yao-Ping Ko et al. J Pers Med. .

Abstract

Background: Scabies is an infectious inflammatory skin disease. Cytokine-mediated inflammatory responses may be one of the pathological mechanisms underlying myocardial infarction.

Objective: We explore the association between scabies and subsequent acute myocardial infarction (AMI) and all-cause mortality; Methods: We conducted a nationwide population-based study using data from the National Health Insurance Research Database (NHIRD) in Taiwan. Patients with scabies (n = 30,184) and 120,739 controls without scabies were included. The primary outcomes were incidental AMI and all-cause mortality. Using Cox proportional-hazards regression analysis, we estimated the risk of acute myocardial infarction for the study cohort; Results: The mean age of the study cohort was 51.81 ± 19.89 years. The adjusted sub-distribution hazard ratios (aSHRs) of AMI were 1.214 (95% CI, 1.068-1.381) after adjusting for demographic characteristics, income, OPD utility frequency, days in hospital, co-morbidities, and medication. The adjusted hazard ratio (aHR) of all-cause mortality after adjusting for age, gender, income, OPD utility frequency, days in hospital, co-morbidities, co-medication, and urbanization was 1.612 (95% CI, 1.557-1.669).

Conclusions: Our study showed that patients with scabies infestations were at higher risk for subsequent AMI and all-cause mortality.

Keywords: NHIRD; acute myocardial infarction; cohort study; scabies.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the study population selection.
Figure 2
Figure 2
Cumulative incidence of AMI in patients with and without scabies. Abbreviation: (AMI), Acute Myocardial Infarction.
Figure 3
Figure 3
Cumulative risk of all-cause mortality in patients with and without scabies.
See this image and copyright information in PMC

References

    1. Thomas C., Coates S.J., Engelman D., Chosidow O., Chang A.Y. Ectoparasites: Scabies. J. Am. Acad. Dermatol. 2020;82:533–548. doi: 10.1016/j.jaad.2019.05.109. - DOI - PubMed
    1. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545–1602. doi: 10.1016/S0140-6736(16)31678-6. - DOI - PMC - PubMed
    1. Jannic A., Bernigaud C., Brenaut E., Chosidow O. Scabies Itch. Dermatol. Clin. 2018;36:301–308. doi: 10.1016/j.det.2018.02.009. - DOI - PubMed
    1. Chung S.D., Wang K.H., Huang C.C., Lin H.C. Scabies increased the risk of chronic kidney disease: A 5-year follow-up study. J. Eur. Acad. Dermatol. Venereol. JEADV. 2014;28:286–292. doi: 10.1111/jdv.12099. - DOI - PubMed
    1. Turkmen K., Mehmet Erdur F., Kucuk A. Risk factors that can affect the progression of chronic kidney disease in patients with poststreptecoccal glomerulonephritis history. Kidney Int. 2013;83:762. doi: 10.1038/ki.2013.15. - DOI - PubMed

LinkOut - more resources