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Clinical Trial
. 1978 May-Jun;78(3):141-7.

[Clinical study of sodium dantroline (Dantrium) in multiple sclerosis (author's transl)]

[Article in French]
R E Gonsette, T Capart, L Demonty
  • PMID: 352084
Clinical Trial

[Clinical study of sodium dantroline (Dantrium) in multiple sclerosis (author's transl)]

[Article in French]
R E Gonsette et al. Acta Neurol Belg. 1978 May-Jun.

Abstract

The authors have studied the antispastic action of Dantrium in 50 patients with multiple sclerosis; in all cases, hypertonia, spasms or clonus constituted a severe obstacle to remedial therapy or nursing. After one year, the authors have found that Dantrium is effective in reducing hypertonia in 40% of the patients, in improving spasms in 65% and in reducing clonus in 50% of the cases. Secondary effects are fairly frequent (60%), characterized in most cases by diminished muscular strength and greater fatigability.

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