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Review
. 2022 Jan 27;58(2):194.
doi: 10.3390/medicina58020194.

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto's Disease and Grave's Disease), Diabetes Mellitus and Obesity

Dorina Galușca  1 , Mihaela Simona Popoviciu  1 , Emilia Elena Babeș  1 , Mădălina Vidican  2 , Andreea Atena Zaha  3 , Vlad Victor Babeș  1 , Alexandru Daniel Jurca  2 , Dana Carmen Zaha  2 , Florian Bodog  4
Affiliations
Review

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto's Disease and Grave's Disease), Diabetes Mellitus and Obesity

Dorina Galușca et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Vitamin D deficiency is involved in numerous pathologies, including endocrine pathology. The purpose of this review consists of presenting the role of vitamin D in the pathophysiology of certain endocrine disorders, autoimmune thyroid disorders (Hashimoto's disease and Grave's disease), diabetes mellitus, and obesity, and whether its supplementation can influence the outcome of these diseases. Materials and Methods: Review articles and original articles from the literature were consulted that corresponded with the thematic. Results: Vitamin D deficiency is frequently encountered in endocrine disorders and supplementation restores the normal values. In Hashimoto's disease, vitamin D deficiency appears to be correlated with a higher titer of anti-TPO antibodies and with thyroid volume, and supplementation was associated with reduction of antibodies in some studies. In other studies, supplementation appeared to reduce TSH levels. In Grave's disease, there was a significant correlation regarding vitamin D levels and thyroid volume respective to the degree of exophthalmos. In diabetes mellitus type 2 patients, supplementation led to some improvement of the HOMA-IR index and HbA1c, whereas obesity data from literature do not report significant beneficial findings. Conclusions: Vitamin D deficiency is highly prevalent in endocrine disorders and its supplementation appears to have numerous beneficial effects.

Keywords: Grave’s disease; Hashimoto’s disease; diabetes mellitus; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Implications of vitamin D in autoimmune thyroid disorders.
Figure 2
Figure 2
Evidence regarding vitamin D deficiency implications in Hashimoto’s disease.
Figure 3
Figure 3
Evidence regarding vitamin D deficiency implications in Grave’s disease.
See this image and copyright information in PMC

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