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. 2022 Jan 30;58(2):208.
doi: 10.3390/medicina58020208.

Toxoplasma gondii Infection in Patients with Psychiatric Disorders from Western Romania

Sebastian Grada  1   2   3 , Alin Gabriel Mihu  1   2   3   4 , Cristina Petrescu  5 , Oana Suciu  5 , Iosif Marincu  1 , Maria Alina Lupu  1   2   6 , Tudor Rares Olariu  1   2   7
Affiliations

Toxoplasma gondii Infection in Patients with Psychiatric Disorders from Western Romania

Sebastian Grada et al. Medicina (Kaunas). .

Abstract

Background and Objectives: High rates of infection with Toxoplasma gondii were found in psychiatric patients globally. In this study, we assessed for the first time the prevalence of T. gondii infection in psychiatric patients and healthy individuals with no known psychiatric disorders in Western Romania. Materials and Methods: The presence of specific IgG anti-T. gondii antibodies was evaluated in 308 psychiatric patients and 296 control subjects using a chemiluminescence assay. Results: Overall, the seroprevalence of IgG antibodies was higher in psychiatric patients (67.86%; 209/308), compared with the control group (54.05%; 160/296) (p < 0.001). Our results revealed a significantly higher prevalence of T. gondii antibodies among patients with schizophrenia (69.77%), organic (personality and behaviour) disorders (76.74%), and mental disorders concerning alcohol abuse (84.62%), compared with the control group (p = 0.009, p = 0.005, p = 0.043, respectively). Conclusions: This study provides new and important information on the seroprevalence of T. gondii in Romanian psychiatric patients and may serve for further scientific research regarding the status of T. gondii infection in patients with psychiatric disorders.

Keywords: Toxoplasma gondii; Western Romania; epidemiology; psychiatric patients; serology.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Yolken R.H., Dickerson F.B., Fuller Torrey E. Toxoplasma and schizophrenia. Parasite Immunol. 2009;31:706–715. doi: 10.1111/j.1365-3024.2009.01131.x. - DOI - PubMed
    1. Montoya J.G., Liesenfeld O. Toxoplasmosis. Lancet. 2004;363:1965–1976. doi: 10.1016/S0140-6736(04)16412-X. - DOI - PubMed
    1. Flegr J., Horáček J. Negative Effects of Latent Toxoplasmosis on Mental Health. Front Psychiatry. 2020;10:1012. doi: 10.3389/fpsyt.2019.01012. - DOI - PMC - PubMed
    1. Mihu A.G., Balta C., Marti D.T., Paduraru A.A., Lupu M.A., Olariu T.R. Seroprevalence of Toxoplasma gondii infection among women of childbearing age in an endemic region of Romania, 2016–2018. Parasite. 2020;27:59. doi: 10.1051/parasite/2020057. - DOI - PMC - PubMed
    1. Olariu T.R., Press C., Talucod J., Olson K., Montoya J.G. Congenital toxoplasmosis in the United States: Clinical and serologic findings in infants born to mothers treated during pregnancy. Parasite. 2019;26:13. doi: 10.1051/parasite/2019013. - DOI - PMC - PubMed