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. 2022 Feb 12;27(4):1243.
doi: 10.3390/molecules27041243.

Effects of Green Apple (Golden Delicious) and Its Three Major Flavonols Consumption on Obesity, Lipids, and Oxidative Stress in Obese Rats

Ilknur Selek Aksoy  1 , Semih Otles  1
Affiliations

Effects of Green Apple (Golden Delicious) and Its Three Major Flavonols Consumption on Obesity, Lipids, and Oxidative Stress in Obese Rats

Ilknur Selek Aksoy et al. Molecules. .

Abstract

Obesity is becoming increasingly common all over the world and global strategies are accordingly being developed to prevent it. In order to support the strategies, the effects of green apple (Golden Delicious) and the consumption of its three major flavonols (quercetin-3-glucoside, quercetin-3-D-galactoside, and quercetin-3-rhamnoside) on body weight; the weight of liver, kidney, and spleen; some lipid parameters in serum; and total lipid ratios of liver and kidney and oxidative stress parameters of obese rats were studied. This study was conducted on two experimental groups: one of which was given an apple, and the other was given flavonols, in addition to their high-energy diet; along with a sham and a control rat group, for 4 weeks. According to results, there was no difference in body and organ weights between groups. The liver and kidney weights increased in obese rats, but there was no difference between the total lipid ratios in these organs. The addition of green apple and selected flavonols to the high-energy diet of rats was not sufficient to prevent the increase in body and organ weights, but it supported the reduction in some lipid fractions and in oxidative stress parameters of obese rats. Moreover, this study supported the argument that obesity causes most of the lipid fractions increase in serum and induces oxidative stress.

Keywords: Golden Delicious; flavonol; lipid; obesity; oxidative stress; quercetin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Quantities of selected minerals and flavonols in green apple.
Figure 2
Figure 2
Comparison of first and last weights averages of 10 rats in groups.
Figure 3
Figure 3
Comparison of organ weights averages of 10 rats in groups. a,b Means in the same group with unlike superscripts differ significantly (p < 0.05).
See this image and copyright information in PMC

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