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Review
. 2022 Feb 18;27(4):1391.
doi: 10.3390/molecules27041391.

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Uday M Muddapur  1 , Sultan Alshehri  2 , Mohammed M Ghoneim  3 , Mater H Mahnashi  4 , Mohammed Abdulrahman Alshahrani  5 , Aejaz Abdullatif Khan  6 , S M Shakeel Iqubal  6 , Amal Bahafi  7 , Sunil S More  8 , Ibrahim Ahmed Shaikh  9 , Basheerahmed Abdulaziz Mannasaheb  3 , Noordin Othman  10   11 , Muazzam Sheriff Maqbul  12 , Mohammad Zaki Ahmad  13
Affiliations
Review

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Uday M Muddapur et al. Molecules. .

Abstract

Bionanotechnology is a branch of science that has revolutionized modern science and technology. Nanomaterials, especially noble metals, have attracted researchers due to their size and application in different branches of sciences that benefit humanity. Metal nanoparticles can be synthesized using green methods, which are good for the environment, economically viable, and facilitate synthesis. Due to their size and form, gold nanoparticles have become significant. Plant materials are of particular interest in the synthesis and manufacture of theranostic gold nanoparticles (NPs), which have been generated using various materials. On the other hand, chemically produced nanoparticles have several drawbacks in terms of cost, toxicity, and effectiveness. A plant-mediated integration of metallic nanoparticles has been developed in the field of nanotechnology to overcome the drawbacks of traditional synthesis, such as physical and synthetic strategies. Nanomaterials' tunable features make them sophisticated tools in the biomedical platform, especially for developing new diagnostics and therapeutics for malignancy, neurodegenerative, and other chronic disorders. Therefore, this review outlines the theranostic approach, the different plant materials utilized in theranostic applications, and future directions based on current breakthroughs in these fields.

Keywords: antibacterial; anticancer; antifungal; antioxidant; cytotoxicity; gold.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(A) Proposed synthetic mechanism for plant-mediated synthesis of gold nanoparticles. (B) The advantages of green synthesis over conventional methods.
Figure 2
Figure 2
Plant parts extract can be used for the biosynthesis of gold nanoparticles.
Figure 3
Figure 3
UV-spectral analysis for gold nanoparticles.
Figure 4
Figure 4
FTIR for gold nanoparticles.
Figure 5
Figure 5
TEM analysis for gold nanoparticles.
Figure 6
Figure 6
XRD analysis for gold nanoparticles.
Figure 7
Figure 7
Theranostic applications of AuNPs in medical sciences and applied fields.
Figure 8
Figure 8
Principle of MTT assay.
See this image and copyright information in PMC

References

    1. Zhang T., Chen P., Sun Y., Xing Y., Yang Y., Dong Y., Xu L., Yang Z., Liu D. A New Strategy Improves Assembly Efficiency of DNA Mono-Modified Gold Nanoparticles. Chem. Commun. 2011;47:5774–5776. doi: 10.1039/c1cc11337b. - DOI - PubMed
    1. Mukherjee P., Bhattacharya R., Bone N., Lee Y.K., Patra C.R., Wang S., Lu L., Secreto C., Banerjee P.C., Yaszemski M.J., et al. Potential Therapeutic Application of Gold Nanoparticles in B-Chronic Lymphocytic Leukemia (BCLL): Enhancing Apoptosis. J. Nanobiotechnology. 2007;5:4. doi: 10.1186/1477-3155-5-4. - DOI - PMC - PubMed
    1. Calzolai L., Franchini F., Gilliland D., Rossi F. Protein–Nanoparticle Interaction: Identification of the Ubiquitin–Gold Nanoparticle Interaction Site. Nano Lett. 2010;10:3101–3105. doi: 10.1021/nl101746v. - DOI - PubMed
    1. Jamison J.A., Bryant E.L., Kadali S.B., Wong M.S., Colvin V.L., Matthews K.S., Calabretta M.K. Altering Protein Surface Charge with Chemical Modification Modulates Protein–Gold Nanoparticle Aggregation. J. Nanopart. Res. 2011;13:625–636. doi: 10.1007/s11051-010-0057-5. - DOI
    1. Uehara N. Polymer-Functionalized Gold Nanoparticles as Versatile Sensing Materials. Anal. Sci. 2010;26:1219–1228. doi: 10.2116/analsci.26.1219. - DOI - PubMed

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