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Review
. 2022 Mar;49(1):73-92.
doi: 10.1016/j.clp.2021.11.005. Epub 2021 Nov 9.

Coronavirus Disease 2019 Infection in Newborns

Jeffrey M Perlman  1 , Christine Salvatore  2
Affiliations
Review

Coronavirus Disease 2019 Infection in Newborns

Jeffrey M Perlman et al. Clin Perinatol. 2022 Mar.

Abstract

Maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can present with or without symptoms at the time of birth. Symptomatic mothers are more likely be associated with preterm births. Population studies demonstrate a consistent association of SARS-CoV-2 infection and a reduction in preterm birth rate. Newborns with positive SARS-CoV-2 test results appear to have minimal burden of illness that is directly associated with a viral infection. Neonatal mortality directly related to SARS-CoV-2 is extremely rare. Maternal vaccination in pregnant women leads to maternal antibody production, and this can occur as early as 5 days after the first vaccination dose.

Keywords: Breast milk; COVID-19; Maternal vaccination; Preterm birth; SARS-CoV-2; Syncytiotrophoblast; Vertical transmission.

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Conflict of interest statement

Disclosure The authors have no commercial or financial conflicts of interest to disclose.

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