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Meta-Analysis
. 2022 Mar;43(3):442-447.
doi: 10.3174/ajnr.A7431. Epub 2022 Feb 24.

ADC for Differentiation between Posttreatment Changes and Recurrence in Head and Neck Cancer: A Systematic Review and Meta-analysis

A Baba  1 , R Kurokawa  2 , M Kurokawa  2 , O Hassan  2 , Y Ota  2 , A Srinivasan  2
Affiliations
Meta-Analysis

ADC for Differentiation between Posttreatment Changes and Recurrence in Head and Neck Cancer: A Systematic Review and Meta-analysis

A Baba et al. AJNR Am J Neuroradiol. 2022 Mar.

Abstract

Background: Previous studies reported that the ADC values of recurrent head and neck cancer lesions are lower than those of posttreatment changes, however, the utility of ADC to differentiate them has not been definitively summarized and established.

Purpose: Our aim was to evaluate the diagnostic benefit of ADC calculated from diffusion-weighted imaging in differentiating recurrent lesions from posttreatment changes in head and neck cancer.

Data sources: MEDLINE, Scopus, and EMBASE data bases were searched for studies.

Study selection: The review identified 6 prospective studies with a total of 365 patients (402 lesions) who were eligible for the meta-analysis.

Data analysis: Forest plots were used to assess the mean difference in ADC values. Heterogeneity among the studies was evaluated using the Cochrane Q test and the I2 statistic.

Data synthesis: Among included studies, the overall mean of ADC values of recurrent lesions was 1.03 × 10-3mm2/s and that of the posttreatment changes was 1.51 × 10-3mm2/s. The ADC value of recurrence was significantly less than that of posttreatment changes in head and neck cancer (pooled mean difference: -0.45; 95% CI, -0.59-0.32, P < .0001) with heterogeneity among studies. The threshold of ADC values between recurrent lesions and posttreatment changes was suggested to be 1.10 × 10-3mm2/s.

Limitations: Given the heterogeneity of the data of the study, the conclusions should be interpreted with caution.

Conclusions: The ADC values in recurrent head and neck cancers are lower than those of posttreatment changes, and the threshold of ADC values between them was suggested.

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Figures

FIG 1.
FIG 1.
The PRISMA 2020 flow chart for the article-selection process. After applying the selection criteria, we identified 6 articles for the systematic review and meta-analysis.
FIG 2.
FIG 2.
Forest plot (association of ADC values between recurrence and posttreatment change). The ADC value of recurrence was significantly smaller than that of posttreatment changes in head and neck cancer.
FIG 3.
FIG 3.
Funnel plot (association of ADC value between recurrence and posttreatment change). The funnel plot identified 2 studies over the pseudo 95% CI.
FIG 4.
FIG 4.
Receiver operating characteristic curve of the cutoff of ADC values between recurrence and posttreatment change.
See this image and copyright information in PMC

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