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Case Reports
. 2022 Feb 15;32(1):011002.
doi: 10.11613/BM.2022.011002.

A sudden creatinine increase: A case report

Bernhard Strasser  1 , Sebastian Strasser  2 , Josef Tomasits  1
Affiliations
Case Reports

A sudden creatinine increase: A case report

Bernhard Strasser et al. Biochem Med (Zagreb). .

Abstract

Creatinine and estimated glomerular filtration rate (eGFR) are first-line laboratory parameters in the diagnosis of various renal diseases. In recent decades, cystatin C (cysC) has furthered the laboratory repertoire regarding renal status assessment and has been implemented in many clinical guidelines. Accordingly, with the establishment of cysC as a renal routine biomarker, further opportunities for assessing eGFR have been attained. Nevertheless, various limitations are still associated with cysC and creatinine analysis. Preanalytical errors could cause false results in both biomarkers. In our case, we were confronted with implausibly elevated creatinine levels due to preanalytical errors.

Keywords: case report; creatinine; cystatin C; estimated glomerular filtration rate.

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Conflict of interest statement

Potential conflict of interest None declared.

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References

    1. Kashani K, Rosner MH, Ostermann M. Creatinine: From physiology to clinical application. Eur J Intern Med. 2020;72:9–14. 10.1016/j.ejim.2019.10.025 - DOI - PubMed
    1. Funamoto M, Shimizu K, Sunagawa Y, Katanasaka Y, Miyazaki Y, Komiyama M, et al. Serum Cystatin C, a Sensitive Marker of Renal Function and Cardiovascular Disease, Decreases After Smoking Cessation. Circ Rep. 2019;1:623–7. 10.1253/circrep.CR-19-0052 - DOI - PMC - PubMed
    1. Zhang W, Zi M, Sun L, Wang F, Chen S, Zhao Y, et al. Cystatin C regulates major histocompatibility complex-II-peptide presentation and extracellular signal-regulated kinase-dependent polarizing cytokine production by bone marrow-derived dendritic cells. Immunol Cell Biol. 2019;97:916–30. 10.1111/imcb.12290 - DOI - PubMed
    1. Ali D, Sacchetto E, Dumontet E, Le Carrer D, Orsonneau JL, Delaroche O, et al. [Hemolysis influence on twenty-two biochemical parameters measurement]. Ann Biol Clin (Paris). 2014;72:297-311. (in French) 10.1684/abc.2014.095210.1684/abc.2014.0952 - DOI - DOI - PubMed
    1. Roelofsen-de Beer RJAC, van Zelst BD, Vroling AB, de Rijke YB, Ramakers C. When results matter: reliable creatinine concentrations in hyperbilirubinemia patients. Clin Chem Lab Med. 2019;57:659–67. 10.1515/cclm-2018-0959 - DOI - PubMed

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