Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 15:2022:6650763.
doi: 10.1155/2022/6650763. eCollection 2022.

Systematic Review of the Efficacy and Safety of Shuxuening Injection in the Treatment of Unstable Angina

Genhao Fan  1 , Menglin Liu  1 , Jia Liu  2 , Xixi Chen  1 , Yuhong Huang  2
Affiliations

Systematic Review of the Efficacy and Safety of Shuxuening Injection in the Treatment of Unstable Angina

Genhao Fan et al. Evid Based Complement Alternat Med. .

Abstract

The aim of this study was to systematically review the efficacy and safety of Shuxuening injection combined with conventional Western medicine in the treatment of unstable angina. Randomized controlled trials of Shuxuening injection combined with conventional Western medicine in the treatment of unstable angina were searched by the computer system from PubMed, EMBASE, Cochrane Library, VIP, CNKI, Wanfang Database, and Chinese Biomedical Database since the establishment of the database until June 2020, according to the inclusion and exclusion criteria for the selection of literature, using Rev Man5.3 Meta-analysis Software. The 28 randomized controlled trials were included, with a total of 3,127 patients. Meta-analysis results showed that Shuxuening injection combined with conventional western medicine was effective in improving the clinical efficacy of angina pectoris (RR = 1.23, 95% CI [1.19, 1.27], P<0.00001), improvement of ECG (RR = 1.31, 95% CI [1.23, 1.40], P < 0.00001), reduction of angina pectoris attack frequency (MD = -1.28, 95% CI [-1.88, -0.67], P < 0.0001), duration of angina (MD = -3.36, 95% CI [-3.69, -3.03], P < 0.00001), nitroglycerin dosage (MD = -0.39, 95% CI [-0.65, -0.13], P = 0.003), C-reactive protein (MD = -2.72, 95% CI [-3.41, -2.03], P < 0.00001), BNP (MD = -23.33, 95% CI [-27.87, -18.79], P < 0.00001), lower triglycerides (MD = -0.72, 95% CI [-1.05, -0.38], P < 0.0001), total cholesterol (MD = -1.39, 95% CI [-1.84, -0.94], P < 0.00001), and LDL cholesterol (MD = -1.20, 95% CI [-2.12, -0.29], P = 0.01) which is better than that of control group. The effect on raising HDL cholesterol was comparable between the two groups (MD = 0.49, 95% CI [-0.06, 1.04], P = 0.08) and the incidence of adverse reactions to differences had no statistical significance (RR = 0.99, 95% CI [0.54, 1.81], P = 0.97). The Shuxuening injection combined with conventional Western medicine in the treatment of unstable angina has clear efficacy and a certain degree of safety, so it is recommended for clinical application.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Document selection process and results.
Figure 2
Figure 2
Percentage of projects included in the study that produced a risk of bias.
Figure 3
Figure 3
Meta-analysis of angina frequency.
Figure 4
Figure 4
Meta-analysis of duration of angina.
Figure 5
Figure 5
Meta-analysis of nitroglycerin dosage.
Figure 6
Figure 6
Meta-analysis of the improvement of electrocardiogram.
Figure 7
Figure 7
Meta-analysis of clinical efficacy of angina.
Figure 8
Figure 8
Meta-analysis of blood fat.
Figure 9
Figure 9
Meta-analysis of CRP.
Figure 10
Figure 10
Meta-analysis of BNP.
Figure 11
Figure 11
Meta-analysis of adverse reactions.
Figure 12
Figure 12
Funnel plot of clinical efficacy of angina.
Figure 13
Figure 13
Funnel plot of ECG improvement.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Shen Y., He G., Xiao T., Yu L. New progress in the diagnosis and treatment of unstable angina. Popular Science and Technology . 2019;21(11):51–53.
    1. Ambrose J. A., Dangas G. Unstable Angina. Archives of Internal Medicine . 2000;160(1):25–37. doi: 10.1001/archinte.160.1.25. - DOI - PubMed
    1. Zhang L., Zhang J., Luo S. Changes in interleukin-27 levels in patients with acute coronary syndrome and their clinical significance. PeerJ . 2019;7e5652 - PMC - PubMed
    1. Hu S. Clinical application and safe use of Shuxuening injection. Journal of Hunan University of Chinese Medicine . 2012;32(11):78–81.
    1. Higgins J. P. T., Altman D. G., Gotzsche P. C. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ . 2011;343 doi: 10.1136/bmj.d5928.d5928 - DOI - PMC - PubMed