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Editorial
. 2021 Dec 13:15:ed118.
doi: 10.3332/ecancer.2021.ed118. eCollection 2021.

PARP inhibitors as a radiosensitizer: a future promising approach in prostate cancer?

Martin Angel  1   2 , Martin Zarba  3 , Juan Pablo Sade  4
Affiliations
Editorial

PARP inhibitors as a radiosensitizer: a future promising approach in prostate cancer?

Martin Angel et al. Ecancermedicalscience. .

Abstract

Poly (ADP-ribose) polymerase (PARP) inhibitors (iPARPs) have shown efficacy in homologous recombination (HR) deficiency patients with advanced castration resistant prostate cancer and have shown a radiosensitizing effect in preclinical and early clinical trials. Preclinical data in prostate cancer cells suggest a similar cytotoxic effect with half the radiation dose under the effect of Olaparib or Rucaparib irrespective of HR status. Due to the biologic synergy of radiotherapy (RT) and iPARPs, the risk of recurrence of high-risk prostate cancer and the morbidity associated with prostate cancer local treatment, this interesting strategy seems promising, and a better understanding of the clinical implications remains to be elucidated.

Keywords: personalized medicine; radiosensitivity; target therapy.

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Conflict of interest statement

None of the authors have conflicts of interest to declare.

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