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Review
. 2022 Jan 31;37(1):e337.
doi: 10.5001/omj.2021.64. eCollection 2022 Jan.

Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies

Putu Nandika Mahardani  1 , Dyah Kanya Wati  2 , Azriel Siloam  1 , Ni Putu Ayu Savitri  1 , Arya Krisna Manggala  1
Affiliations
Review

Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies

Putu Nandika Mahardani et al. Oman Med J. .

Abstract

This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB). We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The keywords were used based on problem, intervention, comparison, and outcome consisted of MDR-TB and STR. Seven cohort studies were selected from 314 studies. The result showed that STR has better therapeutic efficacy and shorter duration than the 2011 World Health Organization regimen for MDR-TB with success rates above 50% in respective studies. The most effective regimen was kanamycin-high-dose isoniazid-clofazimine-ethambutol-prothionamide-pyrazinamide-gatifloxacin in the intensive phase for four months and clofazimine-ethambutol-pyrazinamide-gatifloxacin-prothionamide in the continuation phase for eight months. Gastrointestinal problems, ototoxicity, dysglycemia, and liver problems were the most reported side effects. STR provides good effectiveness in MDR-TB treatment in terms of treatment success rate and short therapy duration.

Keywords: Duration of Therapy; Safety; Tuberculosis, Multidrug-Resistant.

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Figures

Figure 1
Figure 1
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram.
Figure 2
Figure 2
The comparison of treatment success rates of short-term regimen.
See this image and copyright information in PMC

References

    1. World Health Organization. Antimicrobial resistance. 2021 [cited 2021 December 17]. Available from: https://www.who.int/en/news-room/fact- sheets/detail/antimicrobial-resis....
    1. World Health Organization. Global tuberculosis report. Geneva; 2014.
    1. World Health Organization. Global tuberculosis report. Geneva; 2020.
    1. Seung KJ, Keshavjee S, Rich ML. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. Cold Spring Harb Perspect Med 2015. Apr;5(9):a017863. 10.1101/cshperspect.a017863 - DOI - PMC - PubMed
    1. Tr(c)bucq A, Schwoebel V, Kashongwe Z, Bakayoko A, Kuaban C, Noeske J, et al. Treatment outcome with a short multidrug-resistant tuberculosis regimen in nine African countries. Int J Tuberc Lung Dis 2018. Jan;22(1):17-25. 10.5588/ijtld.17.0498 - DOI - PubMed

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