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. 2022 Feb 8:8:804892.
doi: 10.3389/fmed.2021.804892. eCollection 2021.

Prevalence and Impact of Rheumatologic Pain in Cystic Fibrosis Adult Patients

Axelle Schmoll  1 , Claire Launois  1 , Jeanne-Marie Perotin  1   2 , Bruno Ravoninjatovo  1 , Muriel Griffon  1 , Sophie Carré  1 , Pauline Mulette  1 , Julien Ancel  1   2 , Jean Hagenburg  1 , François Lebargy  1   3 , Gaëtan Deslée  1   2 , Jean-Hugues Salmon  4   5 , Sandra Dury  1   3
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Prevalence and Impact of Rheumatologic Pain in Cystic Fibrosis Adult Patients

Axelle Schmoll et al. Front Med (Lausanne). .

Abstract

Background: With the improvement of cystic fibrosis (CF) patient survival, the prevalence of long-term complications increased, among them rheumatologic disorders.

Methods: The aim of this prospective study was to evaluate the prevalence of spinal and joint pain, and their impact on disability, anxiety, depression, and quality of life in CF adult patients.

Results: Forty-seven patients were analyzed, 72% of men, mean aged 28 years, with a mean body mass index of 22 kg/m2 and a mean FEV1% of 63%. Twenty-two patients (47%) described rheumatologic pain either spinal (n = 15, 32%) and/or joint pain (n = 14, 30%). Patients with spinal and/or joint pain were shorter (p = 0.023), more frequently colonized with Staphylococcus aureus (p < 0.008), had more frequent ΔF508 homozygous mutations (p = 0.014), and a trend for more impairment of the 6-min walking distance (p = 0.050). The presence of rheumatologic pain tended to be associated with disability according to the Health Assessment Questionnaire (HAQ) and anxiety. Compared with patients with no pain patients with both spinal and joint pain exhibited a more pronounced impact on the St George's Respiratory Questionnaire (SGRQ).

Conclusion: Rheumatologic pain is frequent in CF adult patients, and may affect daily living, anxiety and quality of life. Systematic assessment of rheumatologic pain should be included in the management of CF patients.

Keywords: cystic fibrosis; joint; pain; quality of life; rheumatologic; spinal.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Bene Z, Fejes Z, Macek M, Jr, Amaral MD, Balogh I, Nagy B, Jr. Laboratory biomarkers for lung disease severity and progression in cystic fibrosis. Clin Chim Acta. (2020) 508:277–86. 10.1016/j.cca.2020.05.015 - DOI - PubMed
    1. Abrami M, Maschio M, Conese M, Confalonieri M, Gerin F, Dapas B, et al. . Combined use of rheology and portable low-field NMR in cystic fibrosis. Respir Med. (2021) 189:106623. 10.1016/j.rmed.2021.106623 - DOI - PubMed
    1. Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, et al. . The future of cystic fibrosis care: a global perpective. Lancet Respir Med. (2020) 8:65–124. 10.1016/S2213-2600(19)30337-6 - DOI - PMC - PubMed
    1. Merkel PA. Rheumatic disease and cystic fibrosis. Arthritis Rheum. (1999) 42:1563–71. - PubMed
    1. Turner MA, Baildam E, Patel L, David TJ. Joint disorders in cystic fibrosis. J R Soc Med. (1997) 90(Suppl. 31):13–20. 10.1177/014107689709031S04 - DOI - PMC - PubMed

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