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. 2022 Feb 8:8:752531.
doi: 10.3389/fcvm.2021.752531. eCollection 2021.

High Intensity Interval Training Leads to Similar Inflammatory Activation as Seen With Traditional Training in Chronic Heart Failure

Arlana G Taylor  1   2 , Andrew I Ignaszewski  2 , Shannon S D Bredin  3   4 , John S Hill  5 , Erin M Shellington  3   4 , Darren E R Warburton  1   3   6
Affiliations

High Intensity Interval Training Leads to Similar Inflammatory Activation as Seen With Traditional Training in Chronic Heart Failure

Arlana G Taylor et al. Front Cardiovasc Med. .

Abstract

Background: Inflammatory activation has been associated with the severity and progression of chronic heart failure (CHF). Although cardiac rehabilitation is an important therapy, acute bouts of exercise may lead to increases in pro-inflammatory cytokines with exercise intensity mediating these changes.

Objective: To evaluate the acute inflammatory response in patients living with CHF during a randomized trial following Steady State (SS) or High Intensity Interval (HIIT) training.

Methods: Patients living with CHF (n = 14) were stratified (for body mass and aerobic power) and randomized into SS and HIIT cycle exercise. The HIIT exercise training involved 2 min work:recovery phases at 90:40% heart rate reserve. The SS exercise training involved continuous exercise at 65% of heart rate reserve (matched total work). Acute inflammatory markers were evaluated (via ELISA) at baseline, immediately following the bout, and at 6, 24, and 48 h post-exercise.

Results: There was limited differences in the changes in inflammatory biomarkers across time between the HIIT and SS groups. Both groups experienced a significant (p < 0.05) change in Interleukin-6 immediately post-exercise.

Conclusions: A single bout of HIIT or SS does not result in excessive inflammatory activation in CHF patients. Acute HIIT and SS result in similar changes in inflammatory markers. These findings have important implications for exercise training and rehabilitation programs in persons living with CHF.

Keywords: cardiac rehabilitation; cytokines; exercise; heart failure; inflammatory markers; interval training; training.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Interleukin-6 (IL-6) as a function of time. Means ± SD. *Main effect for time observed immediately post-exercise (p < 0.05). Circle = Steady State; Square = Interval. Error Bars = ± SEM.
Figure 3
Figure 3
Interleukin-8 (IL-8) as a function of time. Means ± SD. Circle = Steady State; Square = Interval. Error Bars = ± SEM.
Figure 4
Figure 4
Interleukin-10 (IL-10) as a function of time. Means ± SD. Circle = Steady State; Square = Interval. Error Bars = ± SEM.
Figure 5
Figure 5
Tumor Necrosis Factor-alpha (TNF-α) as a function of time. Means ± SD. Circle = Steady State; Square = Interval. Error Bars = ± SEM.
Figure 6
Figure 6
High sensitivity C-Reactive Protein as a function of time. Means ± SD. Circle = Steady State; Square = Interval. Error Bars = ± SEM.
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References

    1. Gielen S, Adams V, Mobius-Winkler S, Linke A, Erbs S, Yu J, et al. . Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. (2003) 42:861–8. 10.1016/S0735-1097(03)00848-9 - DOI - PubMed
    1. Askevold ET, Gullestad L, Dahl CP, Yndestad A, Ueland T, Aukrust P. Interleukin-6 signaling, soluble glycoprotein 130, and inflammation in heart failure. Curr Heart Fail Rep. (2014) 11:146–55. 10.1007/s11897-014-0185-9 - DOI - PubMed
    1. Libera LD, Vescovo G. Muscle wastage in chronic heart failure, between apoptosis, catabolism and altered anabolism: a chimaeric view of inflammation? Curr Opin Clin Nutr Metab Care. (2004) 7:435–41. 10.1097/01.mco.0000134374.24181.5b - DOI - PubMed
    1. Josiak K, Jankowska EA, Piepoli MF, Banasiak W, Ponikowski P. Skeletal myopathy in patients with chronic heart failure: significance of anabolic-androgenic hormones. J Cachexia Sarcopenia Muscle. (2014) 5:287–96. 10.1007/s13539-014-0152-z - DOI - PMC - PubMed
    1. Koshikawa M, Harada M, Noyama S, Kiyono K, Motoike Y, Nomura Y, et al. . Association between inflammation and skeletal muscle proteolysis, skeletal mass and strength in elderly heart failure patients and their prognostic implications. BMC Cardiovasc Disord. (2020) 20:228. 10.1186/s12872-020-01514-0 - DOI - PMC - PubMed

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