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Case Reports
. 2022 Feb 16;10(5):1738-1746.
doi: 10.12998/wjcc.v10.i5.1738.

Neurothekeoma located in the hallux and axilla: Two case reports

Wan-Ying Huang  1 , Yi-Qi Zhang  2 , Xiang-Hong Yang  3
Affiliations
Case Reports

Neurothekeoma located in the hallux and axilla: Two case reports

Wan-Ying Huang et al. World J Clin Cases. .

Abstract

Background: Neurothekeomas (NTKs) are rare benign soft tissue tumours that typically occur in the head, trunk, and upper limbs and are rare in other parts of the body.

Case summary: Herein, we present two rare cases in which primary NTKs were located in the hallux and axilla. A 47-year-old woman complained of a verrucous bulge on the plantar side of the left hallux. The surface skin of the tumour was abraded due to poor wound healing. A 6-year-old boy complained of a gradually growing subcutaneous mass in the axilla. The tumours of both patients were completely resected, and the diagnosis of NTK was confirmed by histopathology. At the one-year follow-up, both patients had a good prognosis without local recurrence.

Conclusion: To date, NTKs located in the hallux and axilla have rarely been reported in the literature. We describe NTKs that occurred in unconventional areas and summarize the challenges in their diagnosis and differential diagnosis.

Keywords: Armpit; Case report; Hallux; Histopathological examination; Immunohistochemical staining; Neurothekeoma.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to report.

Figures

Figure 1
Figure 1
Macropathological and histological analyses of the tumour tissue in case 1. A: Macroscopic image of the verrucous bulge; B-D: Haematoxylin and eosin staining showing the tumour cells (× 200); E-H: Positive immunohistochemical staining for CD10, CD99, transcription factor binding to IGHM enhancer-3 and CD163 (× 200); I-N: Negative immunohistochemical staining for S-100, cytokeratin, EMA, smooth muscle actin, Desmin, Stat6, ALK and NSE (× 200); O and P: Immunohistochemical staining for CD34 and Ki-67 (× 200).
Figure 2
Figure 2
Histological analysis of the tumour tissue in case 2. A-C: Haematoxylin and eosin staining showing the tumour cells (× 200); D-H: Positive immunohistochemical staining for CD10, CD68, transcription factor binding to IGHM enhancer-3, p63 and vimentin (× 200); I-M: Negative immunohistochemical staining for S-100, cytokeratin, smooth muscle actin, glial fibrillary acidic protein and CD1a (× 200); N: Immunohistochemical staining for Ki-67 (× 200).
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