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Meta-Analysis
. 2022 Apr;44(4):409-424.
doi: 10.1055/s-0042-1742409. Epub 2022 Feb 24.

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Rosa Camila Lucchetta  1 , Isabele Held Lemos  1 , Ana Luísa Rodriguez Gini  1 , Sophia de Andrade Cavicchioli  2 , Marcela Forgerini  1 , Fabiana Rossi Varallo  3 , Mariane Nunes de Nadai  4 , Fernando Fernandez-Llimos  5 , Patricia de Carvalho Mastroianni  1
Affiliations
Meta-Analysis

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Rosa Camila Lucchetta et al. Rev Bras Ginecol Obstet. 2022 Apr.

Abstract
in English, Portuguese

Objective: To estimate the prevalence of inadequate vitamin D level and its associated factors for women of childbearing age in Brazil.

Methods: A systematic review was conducted (last updated May 2020). Meta-analyses were performed using the inverse-variance for fixed models with summary proportion calculation by Freeman-Tukey double arcsine. Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies.

Results: Our review identified 31 studies, comprising 4,006 participants. All the studies had at least one weakness, mainly due to the use of convenience sampling and small sample size. The overall prevalence of vitamin D deficiency, insufficiency, and both deficiency and insufficiency were 35% (confidence interval, 95%CI: 34-37%), 42% (95%CI: 41-44%), and 72% (95%CI: 71-74%), respectively.

Conclusion: Although the magnitude of the prevalence of inadequate levels of vitamin D is uncertain, the evidence suggests that presence of vitamin D deficiency or insufficiency in women of reproductive age can cause moderate to severe problems.

Objetivo: Estimar a prevalência de níveis inadequados de vitamina D e seus fatores associados para mulheres em idade fértil no Brasil. MéTODOS: Uma revisão sistemática foi realizada (última atualização em maio de 2020). As meta-análises foram realizadas usando o inverso da variância para o modelo fixo com cálculo de proporção sumarizada por transformação arco-seno duplo de Freeman-Tukey. A qualidade metodológica e de reporte foi avaliada usando a ferramenta do Joanna Briggs Institute para estudos de prevalência.

Resultados: Nossa revisão identificou 31 estudos, compreendendo 4.006 participantes. Todos os estudos apresentaram pelo menos uma limitação, principalmente devido ao uso de amostra de conveniência e tamanho amostral pequeno. As prevalências gerais de deficiência, insuficiência e deficiência de vitamina D foram 35% (intervalo de confiança, IC 95%: 34–37%), 42% (IC 95%: 41–44%) e 72% (IC 95%: 71–74%), respectivamente. CONCLUSãO: Embora a magnitude da prevalência de níveis inadequados de vitamina D seja incerta, a evidência sugere que presença de deficiência ou insuficiência de vitamina D em mulheres em idade reprodutiva pode causar problemas moderados a graves.

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Conflict of interest statement

The authors have no conflict of interests to declare.

Figures

Fig. 1
Fig. 1
( A ) Vitamin D deficiency in pregnant women, women of childbearing age, women in adolescence, and postpartum women; ( B ) Vitamin D insufficiency in pregnant women, women of childbearing age, women in adolescence, and postpartum women.
Fig. 2
Fig. 2
( A ) Vitamin D deficiency along gestational trimesters; ( B ) Vitamin D insufficiency along gestational trimesters.
None
See this image and copyright information in PMC

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