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Review
. 2022 Apr-Jun;45(2):132-143.
doi: 10.1097/CNQ.0000000000000396.

Hemostatic Management in Extracorporeal Membrane Oxygenation

Hannah M Brokmeier  1 , Erin D Wieruszewski, Scott D Nei, Theodore O Loftsgard, Patrick M Wieruszewski
Affiliations
Review

Hemostatic Management in Extracorporeal Membrane Oxygenation

Hannah M Brokmeier et al. Crit Care Nurs Q. 2022 Apr-Jun.

Abstract

The use of extracorporeal membrane oxygenation (ECMO) for acute cardiac and/or respiratory failure has grown exponentially in the past several decades. Systemic anticoagulation is a fundamental element of caring for ECMO patients. Hemostatic management during ECMO walks a fine line to balance the risk of safe and effective anticoagulant delivery to mitigate thromboembolic complications and minimizing hemorrhagic sequelae. This review discusses the pharmacology, monitoring parameters, and special considerations for anticoagulation in patients requiring ECMO.

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Conflict of interest statement

The authors declare no conflict of interest or sources of funding related to the content of this article.

References

    1. Extracorporeal Life Support Organization. Extracorporeal Life Support Registry Report. Ann Arbor, MI: Extracorporeal Life Support Organization; 2021. https://www.elso.org/Registry/Statistics/InternationalSummary.aspx . Accessed August 1, 2021.
    1. Ventetuolo CE, Muratore CS. Extracorporeal life support in critically ill adults. Am J Respir Crit Care Med. 2014;190(5):497–508.
    1. Wieruszewski PM, Barreto EF. Monitoring during extracorporeal membrane oxygenation. In: Stollings JL, ed. CCSAP 2020 Book 2 Issues in Critical Care Practice. Lenexa, KS: American College of Clinical Pharmacy; 2020;63–83.
    1. Beiras-Fernandez A, Deutsch MA, Kainzinger S, et al. Extracorporeal membrane oxygenation in 108 patients with low cardiac output—a single-center experience. Int J Artif Organs. 2011;34(4):365–373.
    1. Mazzeffi M, Greenwood J, Tanaka K, et al. Bleeding, transfusion, and mortality on extracorporeal life support: ECLS working group on thrombosis and hemostasis. Ann Thorac Surg. 2016;101(2):682–689.