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Review
. 2022 Apr-Jun;44(2):232-237.
doi: 10.1590/2175-8239-JBN-2021-0221.

Acute kidney injury associated with dengue virus infection: a review

[Article in English, Portuguese]
Paulo R Bignardi  1 , Gabriela R Pinto  1 , Maria Letícia N Boscarioli  1 , Raissa A A Lima  1 , Vinícius D A Delfino  1   2
Affiliations
Review

Acute kidney injury associated with dengue virus infection: a review

[Article in English, Portuguese]
Paulo R Bignardi et al. J Bras Nefrol. 2022 Apr-Jun.

Abstract
in English, Portuguese

Acute kidney injury (AKI) is one of the least studied complications of dengue, but it carries high mortality rates and prolonged hospital stay. Due to the severity of this complication, the risk of developing chronic kidney disease (CKD) and the increasing number of dengue cases reported worldwide, particularly in the tropical and subtropical regions of Africa, Southeast Asia and South America, including Brazil, we embarked on this narrative review, aimed to update the epidemiology of AKI associated with dengue, elucidate the main pathophysiological mechanisms of AKI caused by the dengue virus infection, as well as discuss useful information on the prevention and management of AKI in patients with dengue.

A injúria renal aguda (IRA) é uma das complicações da dengue menos estudadas, mas que acarreta altas taxas de mortalidade e prolongamento do tempo de internação. Devido à gravidade dessa complicação, ao risco de desenvolvimento de doença renal crônica (DRC) e ao número crescente de casos de dengue relatados no mundo, particularmente nas regiões tropicais e subtropicais da África, Sudeste Asiático e América do Sul, incluindo o Brasil, foi proposta esta revisão narrativa que objetivou atualizar a epidemiologia da IRA associada à dengue, elucidar os principais mecanismos fisiopatológicos da IRA causada pela infecção do vírus da dengue, assim como discutir informações úteis sobre a prevenção e o manejo da IRA em pacientes com dengue.

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Conflict of interest statement

Conflict of Interest

The authors declare that there is no conflict of interest associated with the publication of this manuscript.

Figures

Figure 1
Figure 1. Estimate of AKI incidence in patients with dengue. PD: peritoneal dialysis; HD: hemodialysis; AKI: Acute Kidney Injury.
Figure 2
Figure 2. Risk factors and pathophysiological mechanisms involved in the development of dengue-induced AKI.
See this image and copyright information in PMC

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