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. 2022 Sep;32(5):e2339.
doi: 10.1002/rmv.2339. Epub 2022 Feb 25.

Does dengue and COVID-19 co-infection have worse outcomes? A systematic review of current evidence

Amr Ehab El-Qushayri  1 , Ahmed Mostafa Ahmed Kamel  2 , Abdullah Reda  3 , Sherief Ghozy  4   5
Affiliations

Does dengue and COVID-19 co-infection have worse outcomes? A systematic review of current evidence

Amr Ehab El-Qushayri et al. Rev Med Virol. 2022 Sep.

Abstract

In dengue-endemic regions, the co-infection with SARS-CoV-2 and dengue is a significant health concern. Therefore, we performed a literature search for relevant papers in seven databases on 26 Spetember 2021. Out of 24 articles, the mortality rate and intensive care unit (ICU) admission were 19.1% and 7.8%, respectively. The mean hospital stay was 11.4 days. In addition, we identified two pregnancies with dengue and COVID-19 co-infection; one ended with premature rupture of membrane and intrauterine growth restriction fetus, while the other one ended with maternal mortality and intrauterine fetal death. COVID-19 and dengue co-infection had worse outcomes regarding mortality rates, ICU admission, and prolonged hospital stay. Thus, wise-decision management approaches should be adequately offered to these patients to enhance their outcomes. Establishing an early diagnosis might be the answer to reducing the estimated significant burden of these conditions.

Keywords: COVID-19; SARS-CoV-2; co-infection; dengue; systematic review.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Flow diagram or the study process
FIGURE 2
FIGURE 2
The worldwide distribution of the reported cases of dengue and COVID‐19 co‐infection
See this image and copyright information in PMC

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