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. 2022 Dec;18(12):2603-2613.
doi: 10.1002/alz.12640. Epub 2022 Feb 25.

Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI)

Miriam T Ashford  1 , Rema Raman  2 , Garrett Miller  2 , Michael C Donohue  2 , Ozioma C Okonkwo  3 , Monica Rivera Mindt  4 , Rachel L Nosheny  5 , Godfrey A Coker  2 , Ronald C Petersen  6 , Paul S Aisen  2 , Michael W Weiner  7 ; Alzheimer's Disease Neuroimaging Initiative
Affiliations

Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI)

Miriam T Ashford et al. Alzheimers Dement. 2022 Dec.

Abstract

Introduction: An analysis of the ethnocultural and socioeconomic composition of Alzheimer's Disease Neuroimaging Initiative (ADNI) participants is needed to assess the generalizability of ADNI data to diverse populations.

Methods: ADNI data collected between October 2004 and November 2020 were used to determine ethnocultural and educational composition of the sample and differences in the following metrics: screening, screen fails, enrollment, biomarkers.

Results: Of 3739 screened individuals, 11% identified as being from ethnoculturally underrepresented populations (e.g., Black, Latinx) and 16% had <12 years of education. Of 2286 enrolled participants, 11% identified as ethnoculturally underrepresented individuals and 15% had <12 years of education. This participation is considerably lower than US Census data for adults 60+ (ethnoculturally underrepresented populations: 25%; <12 years of education: 4%). Individuals with <12 years of education failed screening at a higher rate.

Discussion: Our findings suggest that ADNI results may not be entirely generalizable to ethnoculturally diverse and low education populations.

Keywords: Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; biomarkers; diversity; educational attainment; enrollment; ethnicity; race; screening.

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