Multiple Sclerosis Patients and Disease Modifying Therapies: Impact on Immune Responses against COVID-19 and SARS-CoV-2 Vaccination

doi:10.3390/vaccines10020279

Review

. 2022 Feb 11;10(2):279.

doi: 10.3390/vaccines10020279.

Multiple Sclerosis Patients and Disease Modifying Therapies: Impact on Immune Responses against COVID-19 and SARS-CoV-2 Vaccination

Maryam Golshani¹, Jiří Hrdý¹

Affiliations

PMID: 35214735
PMCID: PMC8876554
DOI: 10.3390/vaccines10020279

Review

Multiple Sclerosis Patients and Disease Modifying Therapies: Impact on Immune Responses against COVID-19 and SARS-CoV-2 Vaccination

Maryam Golshani et al. Vaccines (Basel). 2022.

. 2022 Feb 11;10(2):279.

doi: 10.3390/vaccines10020279.

Authors

Maryam Golshani¹, Jiří Hrdý¹

Affiliation

¹ Institute of Immunology and Microbiology, Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.

PMID: 35214735
PMCID: PMC8876554
DOI: 10.3390/vaccines10020279

Abstract

This article reviews the literature on SARS-CoV-2 pandemic and multiple sclerosis (MS). The first part of the paper focuses on the current data on immunopathology of SARS-CoV-2 and leading vaccines produced against COVID-19 infection. In the second part of the article, we discuss the effect of Disease Modifying Therapies (DMTs) on COVID-19 infection severity or SARS-CoV-2 vaccination in MS patients plus safety profile of different vaccine platforms in MS patients.

Keywords: COVID-19; DMTs; SARS-CoV-2; immunosuppression; multiple sclerosis; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Alam T., Qamar S. Coronavirus Disease (COVID-19): Reviews, Applications, and Current Status. J. Inform. Univ. Pamulang. 2020;5:213–219. doi: 10.32493/informatika.v5i3.6563. - DOI
1. Garosi V.H., Tanhaie S., Chaboksavar F., Kamari T., Gheshlaghi P.A., Toghroli R., Soltaninezhad S., Azizi S.A., Yazdani V., Mahmoodi F. An overview of 2019 novel coronavirus COVID-19 pandemic: A review study. J. Educ Health Promot. 2021;10:280. - PMC - PubMed
1. Shi Y., Wang G., Cai X.P., Deng J.W., Zheng L., Zhu H.H., Zheng M., Yang B., Chen Z. An overview of COVID-19. J. Zhejiang Univ. Sci. B. 2020;21:343–360. doi: 10.1631/jzus.B2000083. - DOI - PMC - PubMed
1. Singhal T. A Review of Coronavirus Disease-2019 (COVID-19) Indian J. Pediatr. 2020;87:281–286. doi: 10.1007/s12098-020-03263-6. - DOI - PMC - PubMed
1. Coronavirus Worldometers [Internet] 2022. [(accessed on 1 February 2022)]. Available online: https://www.worldometers.info/coronavirus/

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[1] Alam T., Qamar S. Coronavirus Disease (COVID-19): Reviews, Applications, and Current Status. J. Inform. Univ. Pamulang. 2020;5:213–219. doi: 10.32493/informatika.v5i3.6563. - DOI

[2] Alam T., Qamar S. Coronavirus Disease (COVID-19): Reviews, Applications, and Current Status. J. Inform. Univ. Pamulang. 2020;5:213–219. doi: 10.32493/informatika.v5i3.6563. - DOI

[3] Garosi V.H., Tanhaie S., Chaboksavar F., Kamari T., Gheshlaghi P.A., Toghroli R., Soltaninezhad S., Azizi S.A., Yazdani V., Mahmoodi F. An overview of 2019 novel coronavirus COVID-19 pandemic: A review study. J. Educ Health Promot. 2021;10:280. - PMC - PubMed

[4] Garosi V.H., Tanhaie S., Chaboksavar F., Kamari T., Gheshlaghi P.A., Toghroli R., Soltaninezhad S., Azizi S.A., Yazdani V., Mahmoodi F. An overview of 2019 novel coronavirus COVID-19 pandemic: A review study. J. Educ Health Promot. 2021;10:280. - PMC - PubMed

[5] Shi Y., Wang G., Cai X.P., Deng J.W., Zheng L., Zhu H.H., Zheng M., Yang B., Chen Z. An overview of COVID-19. J. Zhejiang Univ. Sci. B. 2020;21:343–360. doi: 10.1631/jzus.B2000083. - DOI - PMC - PubMed

[6] Shi Y., Wang G., Cai X.P., Deng J.W., Zheng L., Zhu H.H., Zheng M., Yang B., Chen Z. An overview of COVID-19. J. Zhejiang Univ. Sci. B. 2020;21:343–360. doi: 10.1631/jzus.B2000083. - DOI - PMC - PubMed

[7] Singhal T. A Review of Coronavirus Disease-2019 (COVID-19) Indian J. Pediatr. 2020;87:281–286. doi: 10.1007/s12098-020-03263-6. - DOI - PMC - PubMed

[8] Singhal T. A Review of Coronavirus Disease-2019 (COVID-19) Indian J. Pediatr. 2020;87:281–286. doi: 10.1007/s12098-020-03263-6. - DOI - PMC - PubMed

[9] Coronavirus Worldometers [Internet] 2022. [(accessed on 1 February 2022)]. Available online: https://www.worldometers.info/coronavirus/

[10] Coronavirus Worldometers [Internet] 2022. [(accessed on 1 February 2022)]. Available online: https://www.worldometers.info/coronavirus/

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Multiple Sclerosis Patients and Disease Modifying Therapies: Impact on Immune Responses against COVID-19 and SARS-CoV-2 Vaccination

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Multiple Sclerosis Patients and Disease Modifying Therapies: Impact on Immune Responses against COVID-19 and SARS-CoV-2 Vaccination

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