Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Feb 1;11(2):197.
doi: 10.3390/pathogens11020197.

Metabolic Complications of Chronic HIV Infection: A Narrative Review

Affiliations
Review

Metabolic Complications of Chronic HIV Infection: A Narrative Review

Nathan W Cummins. Pathogens. .

Abstract

As persons who are HIV positive and on suppressive antiretroviral therapy live longer, there is increased incidence and recognition of several metabolic complications of this chronic infection. These metabolic complications of HIV infection can result from the infection itself and/or otherwise effective antiviral treatment and can have significant impacts on morbidity and mortality. Some metabolic complications of HIV infection are preventable but most are modifiable, and therefore, active surveillance and screening are warranted. The purpose of this narrative review is to highlight the most common metabolic complications of chronic HIV infection, associated risk factors, diagnosis, and management.

Keywords: HIV; cardiovascular disease; diabetes mellitus; dyslipidemia; osteoporosis.

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

References

    1. Marcus J.L., Chao C.R., Leyden W.A., Xu L., Quesenberry C.P., Klein D.B., Towner W.J., Horberg M.A., Silverberg M.J. Narrowing the Gap in Life Expectancy between HIV-Infected and HIV-Uninfected Individuals with Access to Care. JAIDS J. Acquir. Immune Defic. Syndr. 2016;73:39–46. doi: 10.1097/QAI.0000000000001014. - DOI - PMC - PubMed
    1. Brothers T., Kirkland S., Guaraldi G., Falutz J., Theou O., Johnston B.L., Rockwood K. Frailty in People Aging with Human Immunodeficiency Virus (HIV) Infection. J. Infect. Dis. 2014;210:1170–1179. doi: 10.1093/infdis/jiu258. - DOI - PubMed
    1. Deeks S.G. HIV Infection, Inflammation, Immunosenescence, and Aging. Annu. Rev. Med. 2011;62:141–155. doi: 10.1146/annurev-med-042909-093756. - DOI - PMC - PubMed
    1. Gross A.M., Jaeger P.A., Kreisberg J., Licon K., Jepsen K.L., Khosroheidari M., Morsey B.M., Swindells S., Shen H., Ng C.T., et al. Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA. Mol. Cell. 2016;62:157–168. doi: 10.1016/j.molcel.2016.03.019. - DOI - PMC - PubMed
    1. World Health Organization. 2021. [(accessed on 18 January 2022)]. Available online: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death.