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. 2022 Feb 11;15(2):216.
doi: 10.3390/ph15020216.

Design, Characterization, and Antimicrobial Evaluation of Copper Nanoparticles Utilizing Tamarixinin a Ellagitannin from Galls of Tamarix aphylla

Mohamed A A Orabi  1 , Mounir M Salem-Bekhit  2   3 , Ehab I Taha  4 , El-Shaymaa Abdel-Sattar  5 , Omaish Salman Alqahtani  1 , Fakhria A Al-Joufi  6 , Basel A Abdel-Wahab  7 , Ali Mohamed Alshabi  8 , Hamad S Alyami  9 , Javed Ahmad  9 , Tsutomu Hatano  10
Affiliations

Design, Characterization, and Antimicrobial Evaluation of Copper Nanoparticles Utilizing Tamarixinin a Ellagitannin from Galls of Tamarix aphylla

Mohamed A A Orabi et al. Pharmaceuticals (Basel). .

Abstract

The application of plant extracts or plant-derived compounds in the green synthesis of metal nanoparticles (NPs) was researched. Determining the exact metabolite implicated in the formation of NPs would necessitate comprehensive investigations. Copper nanoparticles (CuNPs) are gaining a lot of attention because of their unique properties and effectiveness against a wide range of bacteria and fungi, as well as their potential for usage in catalytic, optical, electrical, and microelectronics applications. In the course of this study, we aimed to formulate CuNPs utilizing pure tamarixinin A (TA) ellagitannin isolated from Tamarix aphylla galls. The main particle size of the formed CuNPs was 44 ± 1.7 nm with zeta potential equal to -23.7 mV, which emphasize the stability of the CuNPs. The X-ray diffraction spectroscopy showed a typical centered cubic crystalline structure phase of copper. Scanning electron microscopy images were found to be relatively spherical and homogeneous in shape. The antimicrobial properties of TA, as well as its mediated CuNPs, have been evaluated through well diffusion assays against four bacterial, Bacillus subtilis NCTC 10400, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853, and two fungal, Candida albicans and Aspergillus flavus, strains. The distinctive antimicrobial activities were noted against the fungal strains and the Gram-negative bacterial strains P. aeruginosa ATCC 27853, and E. coli ATCC 25922. In conclusion, CuNPs mediated by TA can be applied for combating a wide range of bacterial and fungal species especially C. albicans, Asp. flavus, and P. aeruginosa in a variety of fields.

Keywords: antimicrobial activity; copper nanoparticles; ellagitannins; green synthesis; tamarixinin A.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular structure of tamarixinin A.
Figure 2
Figure 2
Visible spectrum of TA-mediated CuNPs.
Figure 3
Figure 3
XRD pattern of the TA-mediated CuNPs.
Figure 4
Figure 4
Scanning electron microscopic analysis of the TA-mediated CuNPs.
Figure 5
Figure 5
Antibacterial activity of CuNPs against P. aeruginosa ATCC 27853 (5a) and C. albicans ATCC 10237 (5b). (A) Tamarixinin A, (B) Formulated CuNPs using tamarixinin A, and (C) Streptomycin, and Fluconazole (10 mg/mL) positive controls.
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