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Editorial
. 2022 Feb 21;14(4):899.
doi: 10.3390/nu14040899.

Substantial Vitamin D Supplementation Is Required during the Prenatal Period to Improve Birth Outcomes

Bruce W Hollis  1   2 , Carol L Wagner  1   2
Affiliations
Editorial

Substantial Vitamin D Supplementation Is Required during the Prenatal Period to Improve Birth Outcomes

Bruce W Hollis et al. Nutrients. .

Abstract

Vitamin D supplementation during pregnancy has been studied since the early 1980's and, while many clinical trials have been performed, we remain at a crossroads in our conclusions about vitamin D's effects during pregnancy and the optimal dose and timing of supplementation [...].

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Hollis B., Wagner C. The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes. J. Clin. Endocrinol. Metab. 2013;98:4619–4628. doi: 10.1210/jc.2013-2653. - DOI - PMC - PubMed
    1. Hollis B.W., Johnson D., Hulsey T.C., Etbeling M., Wagner C.L. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J. Bone Miner. Res. 2011;26:2341–2357. doi: 10.1002/jbmr.463. - DOI - PMC - PubMed
    1. Hollis B.W., Wagner C.L. Vitamin D and pregnancy: Skeletal effects, nonskeletal effects, and birth outcomes. Calcif. Tissue Int. 2013;92:128–139. doi: 10.1007/s00223-012-9607-4. - DOI - PubMed
    1. Robinson C.J., Alanis M.C., Wagner C.L., Hollis B.W., Johnson D.D. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am. J. Obstet. Gynecol. 2010;203:366.e1–366.e6. doi: 10.1016/j.ajog.2010.06.036. - DOI - PMC - PubMed
    1. Wagner C.L., McNeil R., Hamilton S.A., Winkler J., Cook C.R., Warner G., Bivens B., Davis D.J., Smith P.G., Murphy M., et al. A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina. Am. J. Obstet. Gynecol. 2013;208:137.e1–137.e13. - PMC - PubMed

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