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Review
. 2022 Feb 21;23(4):2358.
doi: 10.3390/ijms23042358.

ISSVA Classification of Vascular Anomalies and Molecular Biology

Kayo Kunimoto  1 , Yuki Yamamoto  1 , Masatoshi Jinnin  1
Affiliations
Review

ISSVA Classification of Vascular Anomalies and Molecular Biology

Kayo Kunimoto et al. Int J Mol Sci. .

Abstract

Vascular anomalies include various diseases, which are classified into two types according to the International Society for the Study of Vascular Anomalies (ISSVA) classification: vascular tumors with proliferative changes of endothelial cells, and vascular malformations primarily consisting of structural vascular abnormalities. The most recent ISSVA classifications, published in 2018, detail the causative genes involved in many lesions. Here, we summarize the latest findings on genetic abnormalities, with the presentation of the molecular pathology of vascular anomalies.

Keywords: infantile hemangioma; lymphatic malformation; venous malformation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Diagram illustrating signaling pathways involved in the pathogenesis of vascular anomalies.
Figure 2
Figure 2
Our hypothetical model of the role of mutations in Tie2, PIK3CA, and Akt in the pathogenesis of venous malformation.
Figure 3
Figure 3
Our hypothetical model of the role of glomulin mutations in the pathogenesis of glomuvenous malformation.
See this image and copyright information in PMC

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