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Comment
. 2022 Mar 14;40(3):240-243.
doi: 10.1016/j.ccell.2022.02.008. Epub 2022 Feb 24.

Intratumoral plasma cells: More than a predictive marker of response to anti-PD-L1 treatment in lung cancer?

Jean-Luc Teillaud  1 , Marie-Caroline Dieu-Nosjean  2
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Comment

Intratumoral plasma cells: More than a predictive marker of response to anti-PD-L1 treatment in lung cancer?

Jean-Luc Teillaud et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Patil et al. report that increased plasma cell signatures are predictive of an extended overall survival in non-small-cell lung cancer patients treated with a PD-L1 inhibitor and that these cells are associated with the presence of tertiary lymphoid structures.

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Conflict of interest statement

Declaration of interests M.-C.D.-N. is inventor on four patent applications (WO 2013/107907, WO 2015/007625, WO 2017/032867, and EP21305176.6) in the field of tumor-associated TLS. J.-L.T. declares no competing interests.

Comment on

  • Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer.
    Patil NS, Nabet BY, Müller S, Koeppen H, Zou W, Giltnane J, Au-Yeung A, Srivats S, Cheng JH, Takahashi C, de Almeida PE, Chitre AS, Grogan JL, Rangell L, Jayakar S, Peterson M, Hsia AW, O'Gorman WE, Ballinger M, Banchereau R, Shames DS. Patil NS, et al. Cancer Cell. 2022 Mar 14;40(3):289-300.e4. doi: 10.1016/j.ccell.2022.02.002. Epub 2022 Feb 24. Cancer Cell. 2022. PMID: 35216676

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