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. 2022 May;117(5):1083-1093.
doi: 10.1016/j.fertnstert.2022.01.013. Epub 2022 Feb 23.

Route of myomectomy and fertility: a prospective cohort study

Lauren A Wise  1 , Laine Thomas  2 , Sophia Anderson  2 , Donna D Baird  3 , Raymond M Anchan  4 , Kathryn L Terry  4 , Erica E Marsh  5 , Ganesa Wegienka  6 , Wanda Kay Nicholson  7 , Kedra Wallace  8 , Robert Bigelow  9 , James Spies  10 , George L Maxwell  11 , Vanessa Jacoby  12 , Evan R Myers  13 , Elizabeth A Stewart  14
Affiliations

Route of myomectomy and fertility: a prospective cohort study

Lauren A Wise et al. Fertil Steril. 2022 May.

Abstract

Objective: To assess prospectively the association between the myomectomy route and fertility.

Design: Prospective cohort study.

Setting: The Comparing Treatments Options for Uterine Fibroids (COMPARE-UF) Study is a multisite national registry of eight clinic centers across the United States.

Patient(s): Reproductive-aged women undergoing surgery for symptomatic uterine fibroids.

Intervention(s): Not applicable.

Main outcome measure(s): We used life-table methods to estimate cumulative probabilities and 95% confidence intervals (CI) of pregnancy and live birth by the myomectomy route during 12, 24, and 36 months of follow-up (2015-2019). We also conducted 12-month interval-based analyses that used logistic regression to estimate odds ratios and 95% CIs for associations of interest. In all analyses, we used propensity score weighting to adjust for differences across surgical routes.

Result(s): Among 1,095 women who underwent myomectomy (abdominal = 388, hysteroscopic = 273, and laparoscopic = 434), 202 reported pregnancy and 91 reported live birth during 36 months of follow-up. There was little difference in the 12-month probability of pregnancy or live birth by route of myomectomy overall or among women intending pregnancy. In interval-based analyses, adjusted ORs for pregnancy were 1.28 (95% CI, 0.76-2.14) for hysteroscopic myomectomy and 1.19 (95% CI, 0.76-1.85) for laparoscopic myomectomy compared with abdominal myomectomy. Among women intending pregnancy, adjusted ORs were 1.27 (95% CI, 0.72-2.23) for hysteroscopic myomectomy and 1.26 (95% CI, 0.77-2.04) for laparoscopic myomectomy compared with abdominal myomectomy. Associations were slightly stronger but less precise for live birth.

Conclusion(s): The probability of conception or live birth did not differ appreciably by the myomectomy route among women observed for 36 months postoperatively.

Clinical trials registration number: (NCT02260752, clinicaltrials.gov).

Keywords: Fibroids; fertility; myomectomy; pregnancy.

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