Platelets for cancer treatment and drug delivery

doi:10.1007/s12094-021-02771-x

Review

. 2022 Jul;24(7):1231-1237.

doi: 10.1007/s12094-021-02771-x. Epub 2022 Feb 26.

Platelets for cancer treatment and drug delivery

Gaozhe Xiao^#¹, Zhikun Zhang^#¹, Qiaoying Chen^#¹, Tao Wu², Wei Shi³, Lu Gan¹, Xiuli Liu¹, Yong Huang¹, Mengyu Lv³, Yongxiang Zhao¹, Pan Wu¹, Liping Zhong¹, Jian He^{4

5}

Affiliations

¹ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.
² The First People's Hospital of Changde City, Changde, 41500, China.
³ The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, 530023, China.
⁴ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China. hejian@gxmu.edu.cn.
⁵ The First People's Hospital of Changde City, Changde, 41500, China. hejian@gxmu.edu.cn.

^# Contributed equally.

PMID: 35218523
DOI: 10.1007/s12094-021-02771-x

Review

Platelets for cancer treatment and drug delivery

Gaozhe Xiao et al. Clin Transl Oncol. 2022 Jul.

. 2022 Jul;24(7):1231-1237.

doi: 10.1007/s12094-021-02771-x. Epub 2022 Feb 26.

Authors

Gaozhe Xiao^#¹, Zhikun Zhang^#¹, Qiaoying Chen^#¹, Tao Wu², Wei Shi³, Lu Gan¹, Xiuli Liu¹, Yong Huang¹, Mengyu Lv³, Yongxiang Zhao¹, Pan Wu¹, Liping Zhong¹, Jian He^{4

5}

Affiliations

¹ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.
² The First People's Hospital of Changde City, Changde, 41500, China.
³ The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, 530023, China.
⁴ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China. hejian@gxmu.edu.cn.
⁵ The First People's Hospital of Changde City, Changde, 41500, China. hejian@gxmu.edu.cn.

^# Contributed equally.

PMID: 35218523
DOI: 10.1007/s12094-021-02771-x

Abstract

Extensive research is currently being conducted into a variety of bio-inspired biomimetic nanoparticles (NPs) with new cell simulation functions across the fields of materials science, chemistry, biology, physics, and engineering. Cells such as erythrocytes, platelets, and stem cells have been engineered as new drug carriers. The platelet-derived drug delivery system, which is a new targeted drug delivery system (TDDS), can effectively navigate the blood circulatory system and interact with the complex tumor microenvironment; it appears to outperform traditional anticancer drugs; hence, it has attracted considerable research interest. In this review, we describe innovative studies and outline the latest progress regarding the use of platelets as tumor targeting and drug delivery vehicles; we also highlight opportunities and challenges relevant to the manufacture of tumor-related platelet TDDSs.

Keywords: Biological carrier; Cancer; Combination therapy; Drug delivery technology; Platelet.

PubMed Disclaimer

Cited by

Tailoring cell-inspired biomaterials to fuel cancer therapy.
Wang QH, Cheng S, Han CY, Yang S, Gao SR, Yin WZ, Song WZ. Wang QH, et al. Mater Today Bio. 2024 Dec 6;30:101381. doi: 10.1016/j.mtbio.2024.101381. eCollection 2025 Feb. Mater Today Bio. 2024. PMID: 39742146 Free PMC article. Review.
Relationship Between Platelets and the Clinical Efficacy of Umbilical Cord Mesenchymal Stem Cells for HBV-Related Acute-on-Chronic Liver Failure and Liver Cirrhosis: A Preliminary Clinical Study.
Zhang K, Jia Y, Shu X, Yang X, Sun H, Cao H, Mei Y, Xiao C. Zhang K, et al. Stem Cells Transl Med. 2023 Jun 15;12(6):325-333. doi: 10.1093/stcltm/szad023. Stem Cells Transl Med. 2023. PMID: 37133409 Free PMC article.
New insights of platelet endocytosis and its implication for platelet function.
Zhou Y, Dong J, Wang M, Liu Y. Zhou Y, et al. Front Cardiovasc Med. 2024 Jan 9;10:1308170. doi: 10.3389/fcvm.2023.1308170. eCollection 2023. Front Cardiovasc Med. 2024. PMID: 38264257 Free PMC article. Review.
A Platelet-Powered Drug Delivery System for Enhancing Chemotherapy Efficacy for Liver Cancer Using the Trojan Horse Strategy.
Huang H, Wang X, Gao Z, Bao H, Yuan X, Chen C, Xia D, Wang X. Huang H, et al. Pharmaceutics. 2024 Jul 5;16(7):905. doi: 10.3390/pharmaceutics16070905. Pharmaceutics. 2024. PMID: 39065602 Free PMC article.
Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency.
Li Z, Lai X, Fu S, Ren L, Cai H, Zhang H, Gu Z, Ma X, Luo K. Li Z, et al. Adv Sci (Weinh). 2022 Aug;9(22):e2201734. doi: 10.1002/advs.202201734. Epub 2022 Jun 2. Adv Sci (Weinh). 2022. PMID: 35652198 Free PMC article. Review.

See all "Cited by" articles

References

1. Cheng WW, Allen TM. Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: a comparison of whole monoclonal antibody, Fab′ fragments and single chain Fv. J Control Release. 2008;1:50–8. - DOI
1. Yue X, Dai Z. Recent advances in liposomal nanohybrid cerasomes as promising drug nanocarriers. Adv Colloid Interface Sci. 2014;207:32–42. - PubMed - DOI
1. Mitchell MJ, Billingsley MM, Haley RM, et al. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101–24. - PubMed - DOI
1. Yin Q, Shen J, Zhang Z, et al. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. Adv Drug Deliv Rev. 2013;13–14:1699–715. - DOI
1. Kolhatkar RB, Swaan P, Ghandehari H. Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly (amidoamine) dendrimers. Pharm Res. 2008;7:1723–9. - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

[1] Cheng WW, Allen TM. Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: a comparison of whole monoclonal antibody, Fab′ fragments and single chain Fv. J Control Release. 2008;1:50–8. - DOI

[2] Cheng WW, Allen TM. Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: a comparison of whole monoclonal antibody, Fab′ fragments and single chain Fv. J Control Release. 2008;1:50–8. - DOI

[3] Yue X, Dai Z. Recent advances in liposomal nanohybrid cerasomes as promising drug nanocarriers. Adv Colloid Interface Sci. 2014;207:32–42. - PubMed - DOI

[4] Yue X, Dai Z. Recent advances in liposomal nanohybrid cerasomes as promising drug nanocarriers. Adv Colloid Interface Sci. 2014;207:32–42. - PubMed - DOI

[5] Mitchell MJ, Billingsley MM, Haley RM, et al. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101–24. - PubMed - DOI

[6] Mitchell MJ, Billingsley MM, Haley RM, et al. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101–24. - PubMed - DOI

[7] Yin Q, Shen J, Zhang Z, et al. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. Adv Drug Deliv Rev. 2013;13–14:1699–715. - DOI

[8] Yin Q, Shen J, Zhang Z, et al. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. Adv Drug Deliv Rev. 2013;13–14:1699–715. - DOI

[9] Kolhatkar RB, Swaan P, Ghandehari H. Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly (amidoamine) dendrimers. Pharm Res. 2008;7:1723–9. - DOI

[10] Kolhatkar RB, Swaan P, Ghandehari H. Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly (amidoamine) dendrimers. Pharm Res. 2008;7:1723–9. - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Platelets for cancer treatment and drug delivery

Affiliations

Platelets for cancer treatment and drug delivery

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical