Platelets for cancer treatment and drug delivery

Gaozhe Xiao^#¹, Zhikun Zhang^#¹, Qiaoying Chen^#¹, Tao Wu², Wei Shi³, Lu Gan¹, Xiuli Liu¹, Yong Huang¹, Mengyu Lv³, Yongxiang Zhao¹, Pan Wu¹, Liping Zhong¹, Jian He^{4

5}

Affiliations

¹ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.
² The First People's Hospital of Changde City, Changde, 41500, China.
³ The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, 530023, China.
⁴ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China. hejian@gxmu.edu.cn.
⁵ The First People's Hospital of Changde City, Changde, 41500, China. hejian@gxmu.edu.cn.

^# Contributed equally.

PMID: 35218523
DOI: 10.1007/s12094-021-02771-x

Review

Platelets for cancer treatment and drug delivery

Gaozhe Xiao et al. Clin Transl Oncol. 2022 Jul.

. 2022 Jul;24(7):1231-1237.

doi: 10.1007/s12094-021-02771-x. Epub 2022 Feb 26.

Authors

Gaozhe Xiao^#¹, Zhikun Zhang^#¹, Qiaoying Chen^#¹, Tao Wu², Wei Shi³, Lu Gan¹, Xiuli Liu¹, Yong Huang¹, Mengyu Lv³, Yongxiang Zhao¹, Pan Wu¹, Liping Zhong¹, Jian He^{4

5}

Affiliations

¹ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.
² The First People's Hospital of Changde City, Changde, 41500, China.
³ The First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, 530023, China.
⁴ National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China. hejian@gxmu.edu.cn.
⁵ The First People's Hospital of Changde City, Changde, 41500, China. hejian@gxmu.edu.cn.

^# Contributed equally.

PMID: 35218523
DOI: 10.1007/s12094-021-02771-x

Abstract

Extensive research is currently being conducted into a variety of bio-inspired biomimetic nanoparticles (NPs) with new cell simulation functions across the fields of materials science, chemistry, biology, physics, and engineering. Cells such as erythrocytes, platelets, and stem cells have been engineered as new drug carriers. The platelet-derived drug delivery system, which is a new targeted drug delivery system (TDDS), can effectively navigate the blood circulatory system and interact with the complex tumor microenvironment; it appears to outperform traditional anticancer drugs; hence, it has attracted considerable research interest. In this review, we describe innovative studies and outline the latest progress regarding the use of platelets as tumor targeting and drug delivery vehicles; we also highlight opportunities and challenges relevant to the manufacture of tumor-related platelet TDDSs.

Keywords: Biological carrier; Cancer; Combination therapy; Drug delivery technology; Platelet.

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References

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Platelets for cancer treatment and drug delivery

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Platelets for cancer treatment and drug delivery

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