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. 2022 Apr-Jun;13(2):100547.
doi: 10.1016/j.jaim.2022.100547. Epub 2022 Feb 23.

Effect of "Murcchana samskara" on therapeutic efficacy of BhallatakadiGhrita

Sandesh R Wayal  1 , Sonali A Barke  2 , Ganesh Nigade  3 , Pradnya Jagtap  3 , Nilambari S Gurav  4 , Satyendra Prasad  5 , Manish Wanjari  6 , Muniappan Ayyanar  7 , Shailendra S Gurav  8
Affiliations

Effect of "Murcchana samskara" on therapeutic efficacy of BhallatakadiGhrita

Sandesh R Wayal et al. J Ayurveda Integr Med. 2022 Apr-Jun.

Abstract

'Bhallatakadi Ghrita' (BG), comprising the plant extracts of Semecarpus anacardium L., Argemone mexicana L., Cocculus hirsutus L., and Woodfordia fruticosa K. 'Murcchana samskara' of ghee before any 'ghrita-paka' preparation evidenced the maximum acceptability for topical application. The current study dealt with the effect of the 'Murcchana' process on the therapeutic efficacy of BG. In the first step, 'Murcchita' ghee was prepared as per reference texts and then developed the 'Murcchita Bhallatakadi Ghrita' (M-BG), which was further assessed for wound healing activity using incision and excision wound animal models. 'Murcchanasamskara' altered the wound healing ability of M-BG (100% wound contraction on 15th post wounding day with 13.50 ± 0.22 days complete re-epithelization time and 562.33 ± 7.37 g breaking strength). The presence of antioxidants, polyphenols, flavonoids, and fatty acids (known for their potential wound healing properties) in M-BG could accelerate the wound contraction rate (P < 0.001). The present investigation has corroborated the Ayurvedic/traditional attribute of 'Murcchanasamskara' to augment the medicinal properties of the BG.

Keywords: Aayurveda; Excision wound; Ghrita; Incision wound; Polyherbal; Wound breaking strength.

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Figures

Fig. 1
Fig. 1
Wound contracting area on post-excision days of ghee (Control), PI ointment USP (Reference Standard), BG (Test) and M-BG (Test) treated groups where; BG- Bhallatakadi Ghrita; M-BG- Murcchita Bhallatakadi Ghrita.
See this image and copyright information in PMC

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