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Review
. 2022 Feb 28;15(1):3-13.
doi: 10.15283/ijsc21251.

Organoid Studies in COVID-19 Research

Jihoon Kim  1 , Bon-Kyoung Koo  2   3 , Hans Clevers  4
Affiliations
Review

Organoid Studies in COVID-19 Research

Jihoon Kim et al. Int J Stem Cells. .

Abstract

The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has completely changed human life for more than two years. Upon the emergence of this new lethal virus, multiple approaches were utilized to gain basic knowledge about its biology. Moreover, modern technologies, such as the organoid model system and next-generation sequencing, enabled us to rapidly establish strategies to tackle the disease, including vaccines and therapeutics. The recently developed organoid technology reflects human physiology more closely than other model systems. Coupled with its rapidness, high efficiency, and outstanding reliability, it has provided an opportunity to develop new drugs and understand the impact of the viral pathogen on the host. Recent findings using organoids have successfully revealed the cellular tropism of the virus in different organs and identified potential drug candidates that impact the disease. This review will summarize current achievements made with organoids in the fight against COVID-19.

Keywords: COVID-19; Organoid; SARS-CoV-2.

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Conflict of interest statement

Potential Conflict of Interest

The authors have no conflicting financial interest.

Figures

Fig. 1
Fig. 1
Overview of organoids on COVID-19 research.
See this image and copyright information in PMC

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