The Relationship between Parkinson's Disease and Acute Myocardial Infarction in Korea : A Nationwide Longitudinal Cohort Study

Abstract

Objective: The goal of the following statewide age and gender-coordinated cohort study in Korea is to find out if there is a link between acute myocardial infarction (AMI) and Parkinson's disease (PD).

Methods: Utilizing the National Health Insurance Sharing Service cohort, patient data were collected. Six thousand four hundred seventy-five individuals with PD were distinguished by utilizing the International Classification of Diseases 10 code G20 and have enrolled in the PD group. The number of participants decreased to 5259 after excluding 1039 patients who were hospitalized less than one time or who visited an outpatient clinic less than twice. Then, 26295 individuals were selected as part of the control group after case control matching was conducted through 1 : 5 age- and gender-coordinated matching. The Cox proportional hazard regression analysis and Kaplan-Meier method were utilized to analyze the likelihood of AMI in PD.

Results: After controlling for age and gender, the hazard ratio of AMI in the PD group was 3.603 (95% confidence interval [CI], 2.837-4.577). After that, the following hazard ratio of AMI in the PD group was modified against for co-morbid medical disorders, resulting in 3.551 (95% CI, 2.795-4.511). According to a subgroup analysis, in males and females aged <65 and aged ≥65 and in the non-diabetes and diabetes, hypertension and non-hypertension, dyslipidemia and non-dyslipidemia subgroups, the AMI incidence rates were dramatically higher in the PD group compared to that of the control.

Conclusion: Individuals with PD have a greater chance of AMI, according to this cross-national study.

Keywords: Epidemiology; Myocardial infarction; Parkinson’s disease; Population.

Fig. 1.

The data formation process is depicted in this flow chart to support this 12-year cohort research utilizing the NHISS cohort. NHISS : National Health Insurance Sharing Service, ICD-10 : International Classification of Diseases 10.

Fig. 2.

The cumulative rates of acute myocardial infarction (AMI) in the Parkinson’s disease (PD) and control groups were compared. The PD and control groups’ cumulative risks of AMI were examined with Kaplan-Meier curves.