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Review
. 2022 Feb;50(2):3000605211059933.
doi: 10.1177/03000605211059933.

Lance Adams syndrome: two cases report and literature review

Yu Guo  1 , Yan Xiao  1 , Li-Fa Chen  1 , De-Hui Yin  1 , Ruo-Dan Wang  1
Affiliations
Review

Lance Adams syndrome: two cases report and literature review

Yu Guo et al. J Int Med Res. 2022 Feb.

Abstract

Hypoxic myoclonus, also known as Lance Adams syndrome, is a rare syndrome that results from the serious brain damage caused by cerebral hypoxia that often follows cardiopulmonary resuscitation. This current case report describes two patients with post-hypoxic myoclonus, both of whom received cardiopulmonary resuscitation. The neurological symptoms of these two patients were significantly improved by the administration of clonazepam and sodium valproate sustained-release tablets. The report presents a literature review detailing the pathogenesis, diagnosis and treatment of Lance Adams syndrome. The timely diagnosis and treatment of Lance Adams syndrome can significantly improve the quality of life of patients. Valproic acid, clonazepam and other antiepileptic drugs can be used. Whether levetiracetam is effective for cortical myoclonus requires further clinical study.

Keywords: Lance Adams syndrome; case report; levetiracetam.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there are no conflicts of interest.

Figures

Figure1.
Figure1.
Brain magnetic resonance imaging of a 59-year-old female patient that presented with involuntary facial twitch for more than 7 years that was a complication of cardiopulmonary resuscitation following surgery. The imaging shows a few lacunar foci in the bilateral lateral ventricles and brain atrophy.
Figure 2.
Figure 2.
Amplitude-integrated electroencephalography of a 59-year-old female patient that presented with involuntary facial twitch for more than 7 years that was a complication of cardiopulmonary resuscitation following surgery. No epileptic wave was found.
Figure 3.
Figure 3.
Brain magnetic resonance imaging of a 48-year-old female patient that presented with radiating pain in her right lower limb. The imaging shows a right frontal lobe lacuna focus and the T2-weighted-fluid-attenuated inversion recovery white matter signal was slightly higher.
Figure 4.
Figure 4.
Amplitude-integrated electroencephalography of a 48-year-old female patient that presented with radiating pain in her right lower limb. The findings were mainly electromyography and shaking artifacts.
See this image and copyright information in PMC

References

    1. Shi X, Bao J, Zhang H, et al.. Emergency medicine in China: A review of the history of progress and current and future challenges after 40 years of reform. Am J Emerg Med 2020; 38: 662–669. - PubMed
    1. Shin JH, Park JM, Kim AR, et al.. Lance-adams syndrome. Ann Rehabil Med 2012; 36: 561–564. - PMC - PubMed
    1. Lance JM, Adams RD. The syndrome of intention or action myoclonus as a sequel to hypoxic encephalopathy. Brain 1963; 86: 111–136. - PubMed
    1. Scheibe F, Neumann WJ, Lange C, et al.. Movement disorders after hypoxic brain injury following cardiac arrest in adults. Eur J Neurol 2020; 27: 1937–1947. - PubMed
    1. van Zijl JC, Beudel M, vd Hoeven HJ, et al.. Electroencephalographic Findings in Posthypoxic Myoclonus. J Intensive Care Med 2016; 31: 270–275. - PubMed